ArticleThe Journal of membrane biology2012
Efficiency of primary saliva secretion: an analysis of parameter dependence in dynamic single-cell and acinus models, with application to aquaporin knockout studies.
Article in The Journal of membrane biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- A Mathematical Exploration of SDH-b Loss in Chromaffin Cells.Bulletin of mathematical biology · 2025Article
- Effects of polyphenols in non-centrifugal cane sugar on saliva secretion:Journal of clinical biochemistry and nutrition · 2023Article
- Calcium Dynamics and Water Transport in Salivary Acinar Cells.Bulletin of mathematical biology · 2021Review
- A Mathematical Model Supports a Key Role for Ae4 (Slc4a9) in Salivary Gland Secretion.Bulletin of mathematical biology · 2018Article
- Computational modeling of epithelial fluid and ion transport in the parotid duct after transfection of human aquaporin-1.American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- Aquaporins in Salivary Glands: From Basic Research to Clinical Applications.International journal of molecular sciences · 2016Review
- Multiscale modelling of saliva secretion.Mathematical biosciences · 2014Article
- Reply to response to 'What do aquaporin knockout studies tell us about fluid transport in epithelia?' Maclaren OJ, Sneyd J, Crampin EJ (2013) J Membr Biol 246:297-305.The Journal of membrane biology · 2014Article
- Response to "What do aquaporin knockout studies tell us about fluid transport in epithelia?" Maclaren OJ, Sneyd J, Crampin EJ (2013) J Membr Biol 246:297-305.The Journal of membrane biology · 2013Article
- What do aquaporin knockout studies tell us about fluid transport in epithelia?The Journal of membrane biology · 2013Article
- A quantitative analysis of electrolyte exchange in the salivary duct.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
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Authors and funding
3 authors.
Funding
Abstract
Secretion from the salivary glands is driven by osmosis following the establishment of osmotic gradients between the lumen, the cell and the interstitium by active ion transport. We consider a dynamic model of osmotically driven primary saliva secretion and use singular perturbation approaches and scaling assumptions to reduce the model. Our analysis shows that isosmotic secretion is the most efficient secretion regime and that this holds for single isolated cells and for multiple cells assembled into an acinus. For typical parameter variations, we rule out any significant synergistic effect on total water secretion of an acinar arrangement of cells about a single shared lumen. Conditions for the attainment of isosmotic secretion are considered, and we derive an expression for how the concentration gradient between the interstitium and the lumen scales with water- and chloride-transport parameters. Aquaporin knockout studies are interpreted in the context of our analysis and further investigated using simulations of transport efficiency with different membrane water permeabilities. We conclude that recent claims that aquaporin knockout studies can be interpreted as evidence against a simple osmotic mechanism are not supported by our work. Many of the results that we obtain are independent of specific transporter details, and our analysis can be easily extended to apply to models that use other proposed ionic mechanisms of saliva secretion.
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