Evidence map›Paper›PMID 22258156›Full record

Trial reportNeurorehabilitation and neural repair2012

Combined central and peripheral stimulation to facilitate motor recovery after stroke: the effect of number of sessions on outcome.

Robert Lindenberg, Lin L Zhu, Gottfried Schlaug

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurorehabilitation and neural repair, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  19. Searching for the optimal tDCS target for motor rehabilitation.Journal of neuroengineering and rehabilitation · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Robert LindenbergBeth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA 02215, USA.
Lin L Zhu
Gottfried Schlaug

Funding

Facilitators of Motor Recovery Following StrokeR01NS045049 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SCHLAUG, GOTTFRIED · 2004 to 2007
$1.3M
NINDS NIH HHS NS045049NINDS NIH HHS R01 NS045049
6 · The paper itself

Abstract

backgroundProof-of-principle studies have demonstrated transient beneficial effects of transcranial direct current stimulation (tDCS) on motor function in stroke patients, mostly after single treatment sessions.

objectiveTo assess the efficacy of multiple treatment sessions on motor outcome.

methodsThe authors examined the effects of two 5-day intervention periods of bihemispheric tDCS and simultaneous occupational/physical therapy on motor function in a group of 10 chronic stroke patients.

resultsThe first 5-day period yielded an increase in Upper-Extremity Fugl-Meyer (UE-FM) scores by 5.9 ± 2.4 points (16.6% ± 10.6%). The second 5-day period resulted in further meaningful, although significantly lower, gains with an additional improvement of 2.3 ± 1.4 points in UE-FM compared with the end of the first 5-day period (5.5% ± 4.2%). The overall mean change after the 2 periods was 8.2 ± 2.2 points (22.9% ± 11.4%).

conclusionThe results confirm the efficacy of bihemispheric tDCS in combination with peripheral sensorimotor stimulation. Furthermore, they demonstrate that the effects of multiple treatment sessions in chronic stroke patients may not necessarily lead to a linear response function, which is of relevance for the design of experimental neurorehabilitation trials.

Indexed as

AdultAgedBiophysicsDouble-Blind MethodElectric Stimulation TherapyFemaleFunctional LateralityHumansMagnetic Resonance ImagingMaleMiddle AgedMotor ActivityMotor CortexOccupational TherapyPhysical Therapy ModalitiesRecovery of Function

Identifiers

PMID22258156
PMCPMC3666327

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.