ArticlePediatric research2012
MR imaging correlates of white-matter pathology in a preterm baboon model.
Article in Pediatric research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Postnatal Nutrition to Improve Brain Development in the Preterm Infant: A Systematic Review From Bench to Bedside.Frontiers in physiology · 2019Pooled it
- Enhancing daily life for children with cognitive developmental delay through insights into brain development.Pediatric research · 2024Review
- Diffuse excessive high signal intensity in the preterm brain on advanced MRI represents widespread neuropathology.NeuroImage · 2022Article
- Evaluation of Rhesus Macaque Models for Cerebral Palsy.Brain sciences · 2022Article
- Perinatal Hyperoxia and Developmental Consequences on the Lung-Brain Axis.Oxidative medicine and cellular longevity · 2022Review
- A Baboon Brain Atlas for Magnetic Resonance Imaging and Positron Emission Tomography Image Analysis.Frontiers in neuroanatomy · 2021Article
- Structural Refinement of the Auditory Brainstem Neurons in Baboons During Perinatal Development.Frontiers in cellular neuroscience · 2021Article
- Respiratory Support of the Preterm Neonate: Lessons About Ventilation-Induced Brain Injury From Large Animal Models.Frontiers in neurology · 2020Review
- Early neuropathological and neurobehavioral consequences of preterm birth in a rabbit model.Scientific reports · 2019Article
- Effects of an artificial placenta on brain development and injury in premature lambs.Journal of pediatric surgery · 2018Article
- White matter injury in the preterm infant: pathology and mechanisms.Acta neuropathologica · 2017Review
- Multimodal image analysis of clinical influences on preterm brain development.Annals of neurology · 2017Article
- Rodent Hypoxia-Ischemia Models for Cerebral Palsy Research: A Systematic Review.Frontiers in neurology · 2016Review
- Is the ferret a suitable species for studying perinatal brain injury?International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2015Review
- Preclinical Models of Encephalopathy of Prematurity.Developmental neuroscience · 2015Review
- Review
- Differential vulnerability of white matter structures to experimental infantile hydrocephalus detected by diffusion tensor imaging.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Article
- The challenge of understanding cerebral white matter injury in the premature infant.Neuroscience · 2014Review
- Magnetic resonance spectroscopy markers of axons and astrogliosis in relation to specific features of white matter injury in preterm infants.Neuroradiology · 2014Article
- Voxel-based clustered imaging by multiparameter diffusion tensor images for glioma grading.NeuroImage. Clinical · 2014Article
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Authors and funding
7 authors.
Funding
Abstract
introductionCerebral white-matter (WM) abnormalities on magnetic resonance imaging (MRI) correlate with neurodevelopmental disability in infants born prematurely.
resultsQuantitative histological measures of WM and ventricular volumes correlated with qualitative MRI scores of WM volume loss and ventriculomegaly. Diffuse astrocytosis was associated with signal abnormality on T(2)-weighted imaging and higher apparent diffusion coefficient in WM. Loss of oligodendrocytes was associated with lower relative anisotropy characterized by higher radial diffusivity values. The relationship between histopathology and MRI abnormalities was more pronounced in animals in the 28 d model, equivalent to the term human infant. DISCUSSION: MRI reflects microstructural and anatomical abnormalities that are characteristic of WM injury in the preterm brain, and these changes are more evident on MRI at term-equivalent postmenstrual age.
methodsWe assessed the histopathological correlates of MRI abnormalities in a baboon model of premature birth. Baboons were delivered at 125 d of gestation (dg, term ~185 dg) and maintained in an animal intensive care unit for 14 (n = 26) or 28 d (n = 17). Gestational control animals were delivered at 140 dg (n = 9) or 153 dg (n = 4). Cerebral WM in fixed brains was evaluated using MRI, diffusion tensor imaging (DTI), and histopathology.
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