Evidence map›Paper›PMID 22257757›Full record

ArticleEmerging infectious diseases2012

Intestinal toxemia botulism in 3 adults, Ontario, Canada, 2006-2008.

Yolanda D Sheppard, Dean Middleton, Yvonne Whitfield, Felix Tyndel, Shariq Haider, Jamie Spiegelman, Richard H Swartz, Mark P Nelder, Stacey L Baker, Lisa Landry and 8 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Emerging infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 53 citations in OpenAlex.

  1. Author's response: Peanut butter confirmed as the source of a case of infant botulism in the United Kingdom, 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
  2. Letter to the editor: Peanut butter confirmed as the source in a case of infant botulism, United Kingdom, 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
  3. Peanut butter confirmed as the source in a case of infant botulism, United Kingdom, 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
  4. Conflicting Clinical Presentation of Infection withJournal of pediatrics. Clinical practice · 2025
    Article
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  17. Botulism mortality in the USA, 1975-2009.The botulinum journal · 2015
    Article
  18. Foodborne botulism in Canada, 1985-2005.Emerging infectious diseases · 2013
    Article
  19. Constipation and poor feeding in an infant with botulism.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 2 countries.

Yolanda D SheppardMinistry of Health and Long-Term Care, Toronto, Ontario, Canada.
Dean Middleton
Yvonne Whitfield
Felix Tyndel
Shariq Haider
Jamie Spiegelman
Richard H Swartz
Mark P Nelder
Stacey L Baker
Lisa Landry
Ross Maceachern
Sherri Deamond
Lorrie Ross
Garth Peters
Michelle Baird
David Rose
Greg Sanders
John W Austin
Regional Municipality of Niagara · CAMinistry of Health and Long Term Care · CASunnybrook Health Science Centre · CAUniversity of California, Irvine · USHealth Sciences Centre · CAHealth Canada · CAHumber River Regional Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Five cases of intestinal toxemia botulism in adults were identified within an 18-month period in or near Toronto, Ontario, Canada. We describe findings for 3 of the 5 case-patients. Clinical samples contained Clostridium botulinum spores and botulinum neurotoxins (types A and B) for extended periods (range 41-61 days), indicative of intestinal toxemia botulism. Patients' clinical signs improved with supportive care and administration of botulinum antitoxin. Peanut butter from the residence of 1 case-patient yielded C. botulinum type A, which corresponded with type A spores found in the patient's feces. The food and clinical isolates from this case-patient could not be distinguished by pulsed-field gel electrophoresis. Two of the case-patients had Crohn disease and had undergone previous bowel surgery, which may have contributed to infection with C. botulinum. These cases reinforce the view that an underlying gastrointestinal condition is a risk factor for adult intestinal toxemia botulism.

Indexed as

Botulinum AntitoxinBotulismClostridium botulinumFecesFemaleHumansMaleMiddle AgedOntarioBotulinum Antitoxin

Identifiers

PMID22257757
PMCPMC3310098
OpenAlexW2000886945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.