Evidence map›Paper›PMID 22257239›Full record

ArticleImmunology2012

The formation of P particle increased immunogenicity of norovirus P protein.

Ming Tan, Xi Jiang

Open access · greenAbstract readComment
In one paragraph

Article in Immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Recent advancements in combination subunit vaccine development.Human vaccines & immunotherapeutics · 2017
    Article
  2. Review
  3. Norovirus.Clinical microbiology reviews · 2015
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Ming TanDivision of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. ming.tan@cchmc.org
Xi Jiang
Cincinnati Children's Hospital Medical Center · USUniversity of Cincinnati Medical Center · US

Funding

Novel vaccine against NorovirusR01AI089634 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI JIANG, XI · 2010 to 2014
$4.7M
NIAID NIH HHS R01 AI089634
6 · The paper itself

Abstract

As a commentary on a recently published paper in Immunology, this article summaries the principle of norovirus P particle as a promising vaccine against noroviruses. It emphasizes the importance of P particle formation in the immune enhancement of the vaccine and methods for production/verification of high quality P particles which may be easily neglected by researchers.

Indexed as

AnimalsCaliciviridae InfectionsFemaleGastroenteritisHumansNorovirusVaccines, Virus-Like ParticleVaccines, Virus-Like Particle

Identifiers

PMID22257239
PMCPMC3372754
OpenAlexW1498124231

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.