ArticleJournal of proteome research2012
Quantotypic properties of QconCAT peptides targeting bovine host response to Streptococcus uberis.
Article in Journal of proteome research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 37 citations in OpenAlex.
- Selected reaction monitoring mass spectrometry of mastitis milk reveals pathogen-specific regulation of bovine host response proteins.Journal of dairy science · 2018Article
- Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 2. Label-free relative quantitative proteomics.Molecular bioSystems · 2016Article
- Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 1. High abundance proteins, acute phase proteins and peptidomics.Molecular bioSystems · 2016Article
- Supernatant protein biomarkers of red blood cell storage hemolysis as determined through an absolute quantification proteomics technology.Transfusion · 2016Article
- The Pig PeptideAtlas: A resource for systems biology in animal production and biomedicine.Proteomics · 2016Article
- Animal board invited review: advances in proteomics for animal and food sciences.Animal : an international journal of animal bioscience · 2015Review
- Host defence related responses in bovine milk during an experimentally induced Streptococcus uberis infection.Proteome science · 2014Article
- Absolute quantification of selected proteins in the human osteoarthritic secretome.International journal of molecular sciences · 2013Article
- A Bovine PeptideAtlas of milk and mammary gland proteomes.Proteomics · 2012Article
- Mass spectrometry quantification of clusterin in the human brain.Molecular neurodegeneration · 2012Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
Abstract
Mammalian host response to pathogens is associated with fluctuations in high abundant proteins in body fluids as well as in regulation of proteins expressed in relatively low copy numbers like cytokines secreted from immune cells and endothelium. Hence, efficient monitoring of proteins associated with host response to pathogens remains a challenging task. In this paper, we present a targeted proteome analysis of a panel of 20 proteins that are widely believed to be key players and indicators of bovine host response to mastitis pathogens. Stable isotope-labeled variants of two concordant proteotypic peptides from each of these 20 proteins were obtained through the QconCAT method. We present the quantotypic properties of these 40 proteotypic peptides and discuss their application to research in host-pathogen interactions. Our results clearly demonstrate a robust monitoring of 17 targeted host-response proteins. Twelve of these were readily quantified in a simple extraction of mammary gland tissues, while the expression levels of the remaining proteins were too low for direct and stable quantification; hence, their accurate quantification requires further fractionation of mammary gland tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.