Evidence map›Paper›PMID 22255587›Full record

ArticleAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference2011

Predictive monitoring for early detection of subacute potentially catastrophic illnesses in critical care.

J Randall Moorman, Craig E Rusin, Hoshik Lee, Lauren E Guin, Matthew T Clark, John B Delos, John Kattwinkel, Douglas E Lake

Abstract read
In one paragraph

Article in Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Data Science for Child Health.The Journal of pediatrics · 2019
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Abnormal heart rate characteristics are associated with abnormal neuroimaging and outcomes in extremely low birth weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2014
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

J Randall MoormanDepartment of Internal Medicine, University of Virginia, Box 800158, Charlottesville, VA 22908, USA. rmoorman@virginia.edu
Craig E Rusin
Hoshik Lee
Lauren E Guin
Matthew T Clark
John B Delos
John Kattwinkel
Douglas E Lake

Funding

Heart rate characteristics monitoring in newborn infantsR01GM064640 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI MOORMAN, JOSEPH RANDALL · 2002 to 2008
$2.4M
Neonatal apnea: Online risk score from new analyses of bedside monitor waveformsRC2HD064488 · NICHD · UNIVERSITY OF VIRGINIA · PI KATTWINKEL, JOHN, MOORMAN, JOSEPH RANDALL · 2009 to 2010
$2.0M
NICHD NIH HHS HD064488NICHD NIH HHS HD064582NICHD NIH HHS RC2 HD064488NIGMS NIH HHS GM064640NIGMS NIH HHS R01 GM064640
6 · The paper itself

Abstract

We wish to save lives of patients admitted to ICUs. Their mortality is high enough based simply on the severity of the original injury or illness, but is further raised by events during their stay. We target those events that are subacute but potentially catastrophic, such as infection. Sepsis, for example, is a bacterial infection of the bloodstream, that is common in ICU patients and has a >25% risk of death. Logically, early detection and treatment with antibiotics should improve outcomes. Our fundamental precepts are (1) some potentially catastrophic medical and surgical illnesses have subclinical phases during which early diagnosis and treatment might have life-saving effects, (2) these phases are characterized by changes in the normal highly complex but highly adaptive regulation and interaction of the nervous system and other organs such as the heart and lungs, (3) teams of clinicians and quantitative scientists can work together to identify clinically important abnormalities of monitoring data, to develop algorithms that match the clinicians' eye in detecting abnormalities, and to undertake the clinical trials to test their impact on outcomes.

Indexed as

Proportional Hazards ModelsCatastrophic IllnessCritical CareDecision Support Systems, ClinicalEarly DiagnosisFemaleHumansInfant, NewbornInfant, Newborn, DiseasesMaleMonitoring, PhysiologicRisk AssessmentRisk FactorsSurvival AnalysisSurvival RateVirginia

Identifiers

PMID22255587
PMCPMC5321075

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.