ArticleAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference2011
Stochastic simulation of cardiac ventricular myocyte calcium dynamics and waves.
Article in Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century.The Journal of physiology · 2016Article
- Hierarchical clustering of ryanodine receptors enables emergence of a calcium clock in sinoatrial node cells.The Journal of general physiology · 2014Article
- Calcium Sparks in the Heart: Dynamics and Regulation.Research and reports in biologyArticle
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Authors and funding
6 authors.
Funding
Abstract
A three dimensional model of calcium dynamics in the rat ventricular myocyte was developed to study the mechanism of calcium homeostasis and pathological calcium dynamics during calcium overload. The model contains 20,000 calcium release units (CRUs) each containing 49 ryanodine receptors. The model simulates calcium sparks with a realistic spontaneous calcium spark rate. It suggests that in addition to the calcium spark-based leak, there is an invisible calcium leak caused by the stochastic opening of a small number of ryanodine receptors in each CRU without triggering a calcium spark. The model also explores the mechanism of calcium wave propagation between release sites under the conditions of calcium overload.
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Registered trials
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