Evidence map›Paper›PMID 22255006›Full record

ArticleAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference2011

Restoring the 3D vestibulo-ocular reflex via electrical stimulation: the Johns Hopkins multichannel vestibular prosthesis project.

Mehdi A Rahman, Chenkai Dai, Gene Y Fridman, Natan S Davidovics, Bryce Chiang, JoongHo Ahn, Russell Hayden, Thuy-Anh N Melvin, Daniel Q Sun, Abderrahmane Hedjoudje and 1 more

4 registry-linked trialsAbstract read
In one paragraph

Article in Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02725463 naactive not recruitingnot on this mapstarted 2016, after this paper: background citation

First-in-Human Early Feasibility Study of Safety, Tolerability and Efficacy for a Multichannel Vestibular Implant in Individuals With Bilateral Severe-to-Profound Loss of Vestibular Sensation

TypeinterventionalSponsorJohns Hopkins UniversityRan2016 to 2028Enrolled30ConditionsOther Disorders of Vestibular Function, Bilateral, Bilateral Vestibular Deficiency (BVD), Gentamicin Ototoxicity, Labyrinth DiseasesArmsLabyrinth Devices MVI™ Multichannel Vestibular Implant
NCT05674786 narecruitingnot on this mapstarted 2023, after this paper: background citation

Vestibular Implantation to Treat Adult-Onset Bilateral Vestibular Hypofunction

TypeinterventionalSponsorJohns Hopkins UniversityRan2023 to 2027Enrolled8ConditionsOther Disorders of Vestibular Function, Bilateral, Bilateral Vestibular Deficiency (BVD), Gentamicin Ototoxicity, Labyrinth DiseasesArmsLabyrinth Devices MVI™ Multichannel Vestibular Implant System
NCT05676944 narecruitingnot on this mapstarted 2023, after this paper: background citation

Vestibular Implantation in Older Adults

TypeinterventionalSponsorJohns Hopkins UniversityRan2023 to 2028Enrolled15ConditionsOther Disorders of Vestibular Function, Bilateral, Bilateral Vestibular Deficiency (BVD), Gentamicin Ototoxicity, Labyrinth DiseasesArmsLabyrinth Devices MVI™ Multichannel Vestibular Implant System
NCT06500975 narecruitingnot on this mapstarted 2024, after this paper: background citation

Long Term Outcomes After Vestibular Implantation

TypeinterventionalSponsorJohns Hopkins UniversityRan2024 to 2029Enrolled32ConditionsBilateral Vestibular Hypofunction, Bilateral Vestibular Deficiency, Bilateral Vestibulopathy, Gentamicin OtotoxicityArmsLabyrinth Devices MVI™ Multichannel Vestibular Implant System
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Development of a multichannel vestibular prosthesis prototype by modification of a commercially available cochlear implant.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mehdi A RahmanDepartments of Otolaryngology-Head & Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Chenkai Dai
Gene Y Fridman
Natan S Davidovics
Bryce Chiang
JoongHo Ahn
Russell Hayden
Thuy-Anh N Melvin
Daniel Q Sun
Abderrahmane Hedjoudje
Charles C Della Santina

Funding

The Physiology of Vestibular CompensationR01DC002390 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI Kathleen E Cullen · 1995 to 2026
$10.7M
Electrical Stimulation to Restore Three Dimensional Vestibular SensationR01DC009255 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI DELLA SANTINA, CHARLES C · 2008 to 2018
$5.7M
Electrical Stimulation to Restore Vestibular FunctionK08DC006216 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI DELLA SANTINA, CHARLES C · 2003 to 2007
$1.0M
Multi-Modal Stimulus Interaction and Optimization in a Vestibular ProsthesisF31DC010099 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI DAVIDOVICS, NATAN SIMCHA · 2009 to 2011
$97k
NIDCD NIH HHS 1F31DC010099NIDCD NIH HHS F31 DC010099NIDCD NIH HHS K08 DC006216NIDCD NIH HHS R01 DC002390NIDCD NIH HHS R01DC002390NIDCD NIH HHS R01 DC009255NIDCD NIH HHS R01DC009255
6 · The paper itself

Abstract

Bilateral loss of vestibular sensation causes difficulty maintaining stable vision, posture and gait. An implantable prosthesis that partly restores normal activity on branches of the vestibular nerve should improve quality of life for individuals disabled by this disorder. We have developed a head-mounted multichannel vestibular prosthesis that restores sufficient semicircular canal function to partially recreate a normal 3-dimensional angular vestibulo-ocular reflex in animals. Here we describe several parallel lines of investigation directed toward refinement of this approach toward eventual clinical application.

Indexed as

Electric StimulationProstheses and ImplantsVestibule, LabyrinthHumansReflex, Vestibulo-Ocular

Identifiers

PMID22255006
PMCPMC3270063

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.