ArticleAmerican journal of cardiovascular disease2012
Patent foramen ovale as a preferential mechanism for increasing the likelihood of brain tumor metastasis.
Article in American journal of cardiovascular disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Brain metastasis mimicking a cavernous angioma as initial presentation of papillary thyroid carcinoma.Endocrinology, diabetes & metabolism case reports · 2024Article
- Cardiac metastasis causes paradoxical malignant embolism.Cancer reports (Hoboken, N.J.) · 2022Article
- Investigation of patent foramen ovale as a mechanism for brain metastasis in patients without prior lung involvement.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metastases are the most common tumors of the central nervous system which may lie dormant behind the brain blood- barrier sheltering from chemiotherapeutic drugs, and whose presence usually indicates a poor prognosis. Development of brain metastases includes the intravasation of the cancer cells through the tumor blood vessels, their circulation within the venous system, passing through the pulmonary filter thus reaching the systemic circulation. Patent foramen ovale (PFO) is a natural communication between the right and left atrium with a prevalence of about 25% in the general population. It may predispose to a right-to-left shunt by-passing the pulmonary filter. Recent literature suggests that the presence of a permanent shunt, large shunt, atrial septal aneurysm and/or venous valve remnants, all increase the risk of paradoxical embolism in PFO patients. The hypothesis that cancer cells may reach the brain circulation through a significant PFO, might open up new fields in brain metastases pathophysiology and prevention.
Indexed as
Identifiers
22254211PMC3257158W94165836What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.