ArticleAmerican journal of cardiovascular disease2011
Cardioprotection by resveratrol: a review of effects/targets in cultured cells and animal tissues.
Article in American journal of cardiovascular disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Review
- GPCR_LigandClassify.py; a rigorous machine learning classifier for GPCR targeting compounds.Scientific reports · 2021Article
- Synthesis of Short-Chain-Fatty-Acid Resveratrol Esters and Their Antioxidant Properties.Antioxidants (Basel, Switzerland) · 2021Article
- Potential Adverse Effects of Resveratrol: A Literature Review.International journal of molecular sciences · 2020Review
- The Plant-Derived Compound Resveratrol in Brain Cancer: A Review.Biomolecules · 2020Review
- Resveratrol Directly Controls the Activity of Neuronal Ryanodine Receptors at the Single-Channel Level.Molecular neurobiology · 2020Article
- Beta-Blockers and Berberine: A Possible Dual Approach to Contrast Neuroblastoma Growth and Progression.Oxidative medicine and cellular longevity · 2020Review
- Phytochemicals as modulators of M1-M2 macrophages in inflammation.Oncotarget · 2018Review
- Polypharmacology or Promiscuity? Structural Interactions of Resveratrol With Its Bandwagon of Targets.Frontiers in pharmacology · 2018Review
- Expression of mTOR/70S6K signaling pathway in pathological scar fibroblasts and the effects of resveratrol intervention.Molecular medicine reports · 2017Article
- Protective effects of resveratrol on autologous nucleus pulposus model of radiculopathy.Experimental and therapeutic medicine · 2016Article
- New Insights on the Use of Dietary Polyphenols or Probiotics for the Management of Arterial Hypertension.Frontiers in physiology · 2016Review
- Article
- Kir6.2-containing ATP-sensitive K(+) channel is required for cardioprotection of resveratrol in mice.Cardiovascular diabetology · 2014Article
- Protective Effects of Resveratrol on TNF-α-Induced Endothelial Cytotoxicity in Baboon Femoral Arterial Endothelial Cells.Journal of diabetes research · 2013Article
- The Protective Role of Resveratrol against Arsenic Trioxide-Induced Cardiotoxicity.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Dietary resveratrol increases the expression of hepatic 7α-hydroxylase and ameliorates hypercholesterolemia in high-fat fed C57BL/6J mice.Lipids in health and disease · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The most widespread form of cardiovascular disease (CVD) in the western world today is atherosclerosis (AS), notably of the major arteries. Despite decades of laboratory, animal, and clinical investigation providing multiple leads and intervention strategies that have resulted in a progressive decline in CVD-related mortality rates, the etiology of AS is incomplete; hence, the need for management and prevention remains imperative. AS is initiated by endothelial cell (EC) injury whereas its progression is promoted by EC interaction with cells that are recruited to the injured endothelium, and additionally, bioactive cytokines and chemokines elaborated by the intercellular interplay. A primary research interest of our laboratory has been the mechanisms that underlie the "French paradox" - an epidemiological association of the co-existence of risk factors with low CVD incidence/mortality rates postulated to attribute to low-to-moderate consumption of red wine and grape-derived polyphenol resveratrol. This review summarizes effects and targets of resveratrol in cultured human aortic and pulmonary aortic endothelial cells (HAEC and HPAEC) and animal tissues, with focus on the resveratrol target protein RTP, N-ribosyldihydro-nicotinamide:quinone oxidoreductase (NQO2).
Indexed as
Identifiers
22254184PMC3253513W1607110199What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.