ArticleInternational journal of Alzheimer's disease2012
Leptin: a novel therapeutic target in Alzheimer's disease?
Article in International journal of Alzheimer's disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Alternative splicing analysis in a Spanish ASD (Autism Spectrum Disorders) cohort: in silico prediction and characterization.Scientific reports · 2025Article
- A systematic study of molecular targets of cannabidiol in Alzheimer's disease.Journal of Alzheimer's disease reports · 2024Review
- Article
- Pathogenesis, Murine Models, and Clinical Implications of Metabolically Healthy Obesity.International journal of molecular sciences · 2022Review
- Novel Marker for Premature Ejaculation: Serum Leptin Level.Sexual medicine · 2022Article
- Nonobese Male Patients with Alzheimer's Disease Are Vulnerable to Decrease in Plasma Leptin.Journal of Alzheimer's disease : JAD · 2022Article
- Sex-specific lipid dysregulation in theBrain communications · 2022Article
- Article
- Metabolically healthy obesity reduces the risk of Alzheimer's disease in elders: a longitudinal study.Aging · 2019Article
- Association between Peripheral Leptin and Adiponectin Levels and Cognitive Decline in Patients with Neurocognitive Disorders ≥65 Years.Journal of Alzheimer's disease : JAD · 2018Article
- Deletion of Alzheimer's Disease Risk Gene ABCA7 Alters White Adipose Tissue Development and Leptin Levels.Journal of Alzheimer's disease reports · 2017Article
- Leptin-mediated ion channel regulation: PI3K pathways, physiological role, and therapeutic potential.Channels (Austin, Tex.) · 2016Review
- The role of leptin in central nervous system diseases.Neuroreport · 2016Review
- The Effects of Leptin Replacement on Neural Plasticity.Neural plasticity · 2016Review
- Beneficial Effect of Leptin on Spatial Learning and Memory in Streptozotocin-Induced Diabetic Rats.Balkan medical journal · 2016Article
- Leptin-induced spine formation requires TrpC channels and the CaM kinase cascade in the hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Circulating biomarkers that predict incident dementia.Alzheimer's research & therapy · 2014Review
- Sexual function improvement in association with serum leptin level elevation in patients with premature ejaculation following sertraline treatment: a preliminary observation.Bosnian journal of basic medical sciences · 2013Article
- Concordance of gene expression in human protein complexes reveals tissue specificity and pathology.Nucleic acids research · 2013Article
- The beneficial effects of leptin on REM sleep deprivation-induced cognitive deficits in mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well established that the hormone leptin circulates in the plasma in amounts proportional to body fat content and it regulates food intake and body weight via its actions in the hypothalamus. However, numerous studies have shown that leptin receptors are widely expressed throughout the CNS and evidence is growing that leptin plays a role in modulating a variety of neuronal processes. In particular, recent studies have highlighted a potential cognitive enhancing role for leptin as it regulates diverse aspects of hippocampal synaptic function that are thought to underlie learning and memory processes including glutamate receptor trafficking, dendritic morphology, and activity-dependent synaptic plasticity. Characterisation of the novel actions of leptin in limbic brain regions is providing valuable insights into leptin's role in higher cognitive functions in health and disease.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.