Evidence map›Paper›PMID 22254086›Full record

ArticleNutrients2011

Differential mammary gland development in FVB and C57Bl/6 mice: implications for breast cancer research.

Mira B MacLennan, Breanne M Anderson, David W L Ma

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

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  14. β-Adrenergic receptor antagonism in mice: a model for pediatric heart disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2013
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mira B MacLennanDepartment of Human Health & Nutritional Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada. mmaclenn@uoguelph.ca
Breanne M Anderson
David W L Ma
University of Guelph · CA

Funding

CIHR MOP-89971
6 · The paper itself

Abstract

A growing body of research suggests a linkage between pubertal mammary gland development and environmental factors such as diet as modifiers of long term breast cancer risk. Much of this research is dependent upon mouse models, which may vary between studies. However, effects may be strain dependent and further modified by diet, which has not been previously examined. Therefore, the objective of the present study was to determine whether mammary gland development differs between FVB and C57Bl/6 strains on diets containing either n-6 or n-3 polyunsaturated fats. Developmental measures related to onset of puberty and mammary gland development differed between strains. Mice fed the n-3 polyunsaturated fatty acids (PUFA) diet were shown to have lower numbers of terminal end buds, a marker of mammary gland development. This study helps to further clarify differences in development and dietary response between FVB and C57Bl/6 mice in order to more appropriately relate mammary gland research to human populations.

Indexed as

AnimalsDietFatty Acids, Omega-3Fatty Acids, Omega-6FemaleMammary Glands, AnimalMiceMice, Inbred C57BLFatty Acids, Omega-3Fatty Acids, Omega-6breast cancerC57Bl/6FVBmammary glandterminal end buds (TEB)

Identifiers

PMID22254086
PMCPMC3257723
OpenAlexW2092990450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.