Trial reportNutrients2011
Folate status of reproductive age women and neural tube defect risk: the effect of long-term folic acid supplementation at doses of 140 µg and 400 µg per day.
Trial report in Nutrients, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Pooled it
- Folic acid causes higher prevalence of detectable unmetabolized folic acid in serum than B-complex: a randomized trial.European journal of nutrition · 2016Trial
- Neither folic acid supplementation nor pregnancy affects the distribution of folate forms in the red blood cells of women.The Journal of nutrition · 2014Trial
- Response of serum and red blood cell folate concentrations to folic acid supplementation depends on methylenetetrahydrofolate reductase C677T genotype: results from a crossover trial.Molecular nutrition & food research · 2013Trial
- Bioequivalence evaluation of a folate-supplemented oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium versus ethinylestradiol/drospirenone and levomefolate calcium alone.Clinical drug investigation · 2012Trial
- Long-term effect of low-dose folic acid intake: potential effect of mandatory fortification on the prevention of neural tube defects.The American journal of clinical nutrition · 2011Trial
- Preconceptional and Periconceptional Folic Acid Supplementation in the Visegrad Group Countries for the Prevention of Neural Tube Defects.Nutrients · 2024Review
- Obstetrical Outcomes in Women With a History of Bladder Augmentation.Health science reports · 2024Article
- Scientific opinion on the tolerable upper intake level for folate.EFSA journal. European Food Safety Authority · 2023Article
- Initiation and duration of folic acid supplementation in preventing congenital malformations.BMC medicine · 2023Article
- Folate - a scoping review for Nordic Nutrition Recommendations 2023.Food & nutrition research · 2023Article
- A study on periconceptional folic acid supplement intake and serum folic acid levels in pregnant mothers.Medical journal, Armed Forces India · 2022Article
- Association between folic acid use during pregnancy and gestational diabetes mellitus: Two population-based Nordic cohort studies.PloS one · 2022Article
- Interaction between Metformin, Folate and Vitamin BInternational journal of molecular sciences · 2021Review
- Maternal Folic Acid Supplementation during Pregnancy and Childhood Allergic Disease Outcomes: A Question of Timing?Nutrients · 2017Review
- Duration of periconceptional folic acid supplementation in women booking for antenatal care.Public health nutrition · 2017Observational
- Knowledge about folic acid supplementation in women presenting for antenatal care.European journal of clinical nutrition · 2016Article
- A review of European guidelines on periconceptional folic acid supplementation.European journal of clinical nutrition · 2016Review
- Clinical utility of serum folate measurement in tertiary care patients: Argument for revising reference range for serum folate from 3.0 ng/mL to 13.0 ng/mL.Practical laboratory medicine · 2015Article
- Population red blood cell folate concentrations for prevention of neural tube defects: Bayesian model.BMJ (Clinical research ed.) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary prevention of most folate-responsive neural tube defects (NTDs) may not require 400 μg folic acid/day but may be achieved by attaining a high maternal folate status. Using RBC folate ≥906 nmol/L as a marker for NTD risk reduction, the study aimed to determine the change in blood folate concentrations in reproductive age women in response to long-term folic acid supplementation at 400 µg/day and 140 µg/day (dose designed to mimic the average daily folic acid intake received from New Zealand's proposed mandatory bread fortification program). Participants were randomly assigned to a daily folic acid supplement of 140 µg (n = 49), 400 µg (n = 48) or placebo (n = 47) for 40 weeks. RBC folate concentrations were measured at baseline, and after 6, 12, 29 and 40 weeks. At 40 weeks, the overall prevalence of having a RBC folate <906 nmol/L decreased to 18% and 35% in the 400 µg and 140 µg groups, respectively, while remaining relatively unchanged at 58% in the placebo group. After 40 weeks, there was no evidence of a difference in RBC folate between the two treatment groups (P = 0.340), nor was there evidence of a difference in the odds of a RBC folate <906 nmol/L (P = 0.078). In conclusion, the average daily intake of folic acid received from the proposed fortification program would increase RBC folate concentrations in reproductive age women to levels associated with a low risk of NTDs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.