ReviewNutrients2010
Evolution of the calcium paradigm: the relation between vitamin D, serum calcium and calcium absorption.
Review in Nutrients, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Management of osteoporosis with calcitriol in elderly Chinese patients: a systematic review.Clinical interventions in aging · 2014Pooled it
- The Brown AlgaeNutrients · 2022Article
- Effects of In Ovo Vitamin DThe journal of poultry science · 2019Article
- 25-Hydroxyvitamin D level does not reflect intestinal calcium absorption: an assay using strontium as a surrogate marker.Journal of bone and mineral metabolism · 2015Article
- No vitamin D threshold for calcium absorption: why does this matter?The American journal of clinical nutrition · 2014Article
- A rare complication after intertrochanteric fracture treated with proximal femoral nail: femoral neck insufficiency fracture.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2013Article
- Defining vitamin D deficiency, using surrogate markers.Indian journal of endocrinology and metabolism · 2013Article
- The intestinal calcistat: Determinant of clinical vitamin D deficiency.Indian journal of endocrinology and metabolism · 2013Article
- Osteoporosis prevention--a worthy and achievable strategy.Nutrients · 2010Article
- Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis is the index disease for calcium deficiency, just as rickets/osteomalacia is the index disease for vitamin D deficiency, but there is considerable overlap between them. The common explanation for this overlap is that hypovitaminosis D causes malabsorption of calcium which then causes secondary hyperparathyroidism and is effectively the same thing as calcium deficiency. This paradigm is incorrect. Hypovitaminosis D causes secondary hyperparathyroidism at serum calcidiol levels lower than 60 nmol/L long before it causes malabsorption of calcium because serum calcitriol (which controls calcium absorption) is maintained until serum calcidiol falls below 20 nmol/L. This secondary hyperparathyroidism, probably due to loss of a "calcaemic" action of vitamin D on bone first described in 1957, destroys bone and explains why vitamin D insufficiency is a risk factor for osteoporosis. Vitamin D thus plays a central role in the maintenance of the serum (ionised) calcium, which is more important to the organism than the preservation of the skeleton. Bone is sacrificed when absorbed dietary calcium does not match excretion through the skin, kidneys and bowel which is why calcium deficiency causes osteoporosis in experimental animals and, by implication, in humans.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.