ReviewNutrients2010
Long-chain omega-3 polyunsaturated fatty acids may be beneficial for reducing obesity-a review.
Review in Nutrients, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02923453 (Efficacy and Safety of American Ginseng), which is not on this map. Cited by 84 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Safety of American Ginseng (Penax Quinquefolius) Extract on Glycemic Control in Individuals With Type 2 Diabetes: A Double-blind, Randomized, Crossover Clinical Trial
Who cites it
84 citing papers in PubMed, 3 syntheses or guidelines pooled it, 229 citations in OpenAlex.
- The Effect of Canola Oil on Body Weight and Composition: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials.Advances in nutrition (Bethesda, Md.) · 2019Pooled it
- Efficacy of Omega-3 Polyunsaturated Fatty Acids Supplementation in Managing Overweight and Obesity: A Meta-Analysis of Randomized Clinical Trials.The journal of nutrition, health & aging · 2017Pooled it
- Does Fish Oil Have an Anti-Obesity Effect in Overweight/Obese Adults? A Meta-Analysis of Randomized Controlled Trials.PloS one · 2015Pooled it
- Supplementation of EPA and DHA in pregnant women with type 1 diabetes mellitus.Annals of medicine · 2021Trial
- Omega-3 fatty acids does not affect physical activity and body weight in primary school children - a double-blind randomized placebo-controlled trial.Scientific reports · 2018Trial
- A calorie-restriction diet supplemented with fish oil and high-protein powder is associated with reduced severity of metabolic syndrome in obese women.European journal of clinical nutrition · 2015Trial
- A randomized longitudinal dietary intervention study during pregnancy: effects on fish intake, phospholipids, and body composition.Nutrition journal · 2015Trial
- Trial
- DNA methylation pattern in overweight women under an energy-restricted diet supplemented with fish oil.BioMed research international · 2014Trial
- Long-Chain n-3 Polyunsaturated Fatty Acids Attenuate the Severity of Obesity-Associated White Adipose Tissue and Skeletal Muscle Dysfunction.Marine drugs · 2026Review
- Omega-3 supplementation and cardiometabolic risk factors in obese/overweight children and adolescents: a GRADE assessed systematic review and meta-analysis.Nutrition & metabolism · 2025Review
- Omega-3 Fatty Acids and Chronic Lung Diseases: A Narrative Review of Impacts from Womb to Tomb.The Journal of nutrition · 2025Review
- Interaction of genetics risk score and fatty acids quality indices on healthy and unhealthy obesity phenotype.BMC medical genomics · 2025Article
- Maternal supplementation with chia oil attenuates hepatic metabolic disturbances in mice subjected to postnatal undernutrition.Frontiers in nutrition · 2025Article
- The Anti-Obesity Effect of Fish Oil in Diet-Induced Obese Mice Occurs via Both Decreased Food Intake and the Induction of Heat Production Genes in Brown but Not White Adipose Tissue.International journal of molecular sciences · 2024Article
- The impact of substituting clarified butter with canola oil on the components of metabolic syndrome, fatty liver index, and insulin resistance among individuals diagnosed with metabolic syndrome: a quasi-experimental study.Journal of diabetes and metabolic disorders · 2024Article
- Effects of 17,18-EEQ analog (TZ-1) on brown adipogenesis and browning of human adipose-derived stromal cells.Biochemical and biophysical research communications · 2024Article
- Mechanism of Obesity-Related Lipotoxicity and Clinical Perspective.Advances in experimental medicine and biology · 2024Review
- Fish oil supplementation in obese rats ameliorates metabolic syndrome response.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024Article
- Comparison of nutritional value of snakehead fish from Guangdong and Deqing varieties.PloS one · 2024Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current recommendations for counteracting obesity advocate the consumption of a healthy diet and participation in regular physical activity, but many individuals have difficulty complying with these recommendations. Studies in rodents and humans have indicated that long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA) potentially elicit a number of effects which might be useful for reducing obesity, including suppression of appetite, improvements in circulation which might facilitate nutrient delivery to skeletal muscle and changes in gene expression which shift metabolism toward increased accretion of lean tissue, enhanced fat oxidation and energy expenditure and reduced fat deposition. While LC n-3 PUFA supplementation has been shown to reduce obesity in rodents, evidence in humans is limited. Epidemiological associations between LC n-3 PUFA intakes and obesity are inconclusive but small cross-sectional studies have demonstrated inverse relationships between markers of LC n-3 PUFA status and markers of obesity. Human intervention trials indicate potential benefits of LC n-3 PUFA supplementation, especially when combined with energy-restricted diets or exercise, but more well-controlled and long-term trials are needed to confirm these effects and identify mechanisms of action.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.