Evidence map›Paper›PMID 22254000›Full record

ReviewNutrients2010

Polyphenols and human health: prevention of disease and mechanisms of action.

David Vauzour, Ana Rodriguez-Mateos, Giulia Corona, Maria Jose Oruna-Concha, Jeremy P E Spencer

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05432362 (ESAN II - Energy Sensing in Depression. Effects of Aronia Melanocarpa on Immunomodulation in Patients With Obesity, Depression, and Normal Weight Controls.), which is not on this map. Cited by 284 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
284citing papers in PubMed, 3 pooled it
8.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05432362 narecruitingnot on this mapstarted 2019, after this paper: background citation

ESAN II - Energy Sensing in Depression. Effects of Aronia Melanocarpa on Immunomodulation in Patients With Obesity, Depression, and Normal Weight Controls.

TypeinterventionalSponsorMedical University of GrazRan2019 to 2026Enrolled120ConditionsImmune System Tolerance, Depression, Obesity, Microbial ColonizationArmsAronia Juice, Placebo
3 · Its place in the literature

Who cites it

284 citing papers in PubMed, 3 syntheses or guidelines pooled it, 820 citations in OpenAlex.

  1. When bad turns good: a systematic review on cholesterol and LDL in longitudinal patient cohorts with Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Pooled it
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  18. Advanced Oral Delivery Systems for Nutraceuticals.Advanced healthcare materials · 2025
    Review
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224 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

David VauzourMolecular Nutrition Group, Department of Food and Nutritional Sciences, School of Chemistry, Food and Pharmacy, The University of Reading, UK. d.vauzour@reading.ac.uk
Ana Rodriguez-Mateos
Giulia Corona
Maria Jose Oruna-Concha
Jeremy P E Spencer
University of Reading · GB

Funding

Biotechnology and Biological Sciences Research Council BB/E023185/1Biotechnology and Biological Sciences Research Council BB/F008953/1Biotechnology and Biological Sciences Research Council BB/G005702/1
6 · The paper itself

Abstract

Polyphenols are found ubiquitously in plants and their regular consumption has been associated with a reduced risk of a number of chronic diseases, including cancer, cardiovascular disease (CVD) and neurodegenerative disorders. Rather than exerting direct antioxidant effects, the mechanisms by which polyphenols express these beneficial properties appear to involve their interaction with cellular signaling pathways and related machinery that mediate cell function under both normal and pathological conditions. We illustrate that their interactions with two such pathways, the MAP kinase (ERK, JNK, p38) and PI3 kinase/Akt signaling cascades, allow them to impact upon normal and abnormal cell function, thus influencing the cellular processes involved in the initiation and progression of cancer, CVD and neurodegeneration. For example, their ability to activate ERK in neurons leads to a promotion of neuronal survival and cognitive enhancements, both of which influence the progression of Alzheimer's disease, whilst ERK activation by polyphenols in vascular endothelial cells influences nitric oxide production, blood pressure and ultimately CVD risk. The main focus of this review is to provide an overview of the role that polyphenols play in the prevention of cancer, cardiovascular disease and neurodegeneration. We present epidemiological data, human intervention study findings, as well as animal and in vitro studies in support of these actions and in each case we consider how their actions at the cellular level may underpin their physiological effects.

Indexed as

AnimalsBlood PressureCardiovascular DiseasesEndothelial CellsFemaleHumansMaleMAP Kinase Signaling SystemNeoplasmsNeurodegenerative DiseasesNitric OxidePhosphatidylinositol 3-KinasesPolyphenolsProto-Oncogene Proteins c-aktSignal TransductionNitric OxidePhosphatidylinositol 3-KinasesPolyphenolsProto-Oncogene Proteins c-aktadvanced glycation end productscancercardiovascular diseaseneurodegenerationpolyphenolssignaling pathways

Identifiers

PMID22254000
PMCPMC3257622
OpenAlexW2053058287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.