Evidence map›Paper›PMID 22253988›Full record

ArticleNutrients2010

NMR-metabolic methodology in the study of GM foods.

Anatoly P Sobolev, Donatella Capitani, Donato Giannino, Chiara Nicolodi, Giulio Testone, Flavio Santoro, Giovanna Frugis, Maria A Iannelli, Autar K Mattoo, Elvino Brosio and 3 more

Abstract read
In one paragraph

Article in Nutrients, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Metabolomics of genetically modified crops.International journal of molecular sciences · 2014
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anatoly P SobolevInstitute of Chemical Methodologies, Magnetic Resonance Laboratory Annalaura Segre, CNR, Via Salaria km 29.300, 00015 Monterotondo, Rome, Italy. anatoli.sobolev@imc.cnr.it
Donatella Capitani
Donato Giannino
Chiara Nicolodi
Giulio Testone
Flavio Santoro
Giovanna Frugis
Maria A Iannelli
Autar K Mattoo
Elvino Brosio
Raffaella Gianferri
Irene D'Amico
Luisa Mannina

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 1H-NMR methodology used in the study of genetically modified (GM) foods is discussed. Transgenic lettuce (Lactuca sativa cv "Luxor") over-expressing the ArabidopsisKNAT1 gene is presented as a case study. Twenty-two water-soluble metabolites (amino acids, organic acids, sugars) present in leaves of conventional and GM lettuce were monitored by NMR and quantified at two developmental stages. The NMR spectra did not reveal any difference in metabolite composition between the GM lettuce and the wild type counterpart. Statistical analyses of metabolite variables highlighted metabolism variation as a function of leaf development as well as the transgene. A main effect of the transgene was in altering sugar metabolism.

Indexed as

Amino AcidsArabidopsisArabidopsis ProteinsCarbohydrate MetabolismCarboxylic AcidsHomeodomain ProteinsHumansLactucaMagnetic Resonance SpectroscopyPlant LeavesPlants, Genetically ModifiedAmino AcidsArabidopsis ProteinsCarboxylic AcidsHomeodomain ProteinsKNAT1 protein, Arabidopsisgenetically modified foodNMR metabolic profilingtransgenic lettuce

Identifiers

PMID22253988
PMCPMC3257611

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.