ArticlePloS one2012
A2BR adenosine receptor modulates sweet taste in circumvallate taste buds.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- The P2YPurinergic signalling · 2025Article
- A "Dock-Work" Orange: A Dual-Receptor Biochemical Theory on the Deterrence Induced by Citrusy Aroma on Elephant Traffic Central to a Conservation Effort.Bioinformatics and biology insights · 2025Article
- Adenosine metabolized from extracellular ATP promotes type 2 immunity through triggering ACell reports · 2022Article
- Taste Bud Connectome: Implications for Taste Information Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The Role of ATP and Purinergic Receptors in Taste Signaling.Handbook of experimental pharmacology · 2022Review
- Article
- Calcium signaling in taste cells.Biochimica et biophysica acta · 2015Review
- Taste perception, associated hormonal modulation, and nutrient intake.Nutrition reviews · 2015Review
- Synaptic communication and signal processing among sensory cells in taste buds.The Journal of physiology · 2014Article
- Probing biased/partial agonism at the G protein-coupled A(2B) adenosine receptor.Biochemical pharmacology · 2014Article
- Expression of adenosine A2b receptor in rat type II and III taste cells.Histochemistry and cell biology · 2014Article
- Interleukin-10 is produced by a specific subset of taste receptor cells and critical for maintaining structural integrity of mouse taste buds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- A taste for ATP: neurotransmission in taste buds.Frontiers in cellular neuroscience · 2013Review
- Role of the ectonucleotidase NTPDase2 in taste bud function.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- SKCa Channels Blockage Increases the Expression of Adenosine A2A Receptor in Jurkat Human T Cells.BioResearch open access · 2013Article
- Taste buds as peripheral chemosensory processors.Seminars in cell & developmental biology · 2013Review
- Human biology of taste.Annals of Saudi medicineReview
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
In response to taste stimulation, taste buds release ATP, which activates ionotropic ATP receptors (P2X2/P2X3) on taste nerves as well as metabotropic (P2Y) purinergic receptors on taste bud cells. The action of the extracellular ATP is terminated by ectonucleotidases, ultimately generating adenosine, which itself can activate one or more G-protein coupled adenosine receptors: A1, A2A, A2B, and A3. Here we investigated the expression of adenosine receptors in mouse taste buds at both the nucleotide and protein expression levels. Of the adenosine receptors, only A2B receptor (A2BR) is expressed specifically in taste epithelia. Further, A2BR is expressed abundantly only in a subset of taste bud cells of posterior (circumvallate, foliate), but not anterior (fungiform, palate) taste fields in mice. Analysis of double-labeled tissue indicates that A2BR occurs on Type II taste bud cells that also express Gα14, which is present only in sweet-sensitive taste cells of the foliate and circumvallate papillae. Glossopharyngeal nerve recordings from A2BR knockout mice show significantly reduced responses to both sucrose and synthetic sweeteners, but normal responses to tastants representing other qualities. Thus, our study identified a novel regulator of sweet taste, the A2BR, which functions to potentiate sweet responses in posterior lingual taste fields.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.