ArticlePloS one2012
Characterization of a novel association between two trypanosome-specific proteins and 5S rRNA.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Trypanosoma brucei L11 Is Essential to Ribosome Biogenesis and Interacts with the Kinetoplastid-Specific Proteins P34 and P37.mSphere · 2019Article
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- The Nuclear Export Receptors TbMex67 and TbMtr2 Are Required for Ribosome Biogenesis in Trypanosoma brucei.mSphere · 2019Article
- Article
- Kinetoplastid Specific RNA-Protein Interactions in Trypanosoma cruzi Ribosome Biogenesis.PloS one · 2015Article
- Article
- Defining the RNA-protein interactions in the trypanosome preribosomal complex.Eukaryotic cell · 2013Article
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- Association of a novel preribosomal complex in Trypanosoma brucei determined by fluorescence resonance energy transfer.Eukaryotic cell · 2013Article
- Molecular and functional characterization of a Trypanosoma cruzi nuclear adenylate kinase isoform.PLoS neglected tropical diseases · 2013Article
- A novel association between two trypanosome-specific factors and the conserved L5-5S rRNA complex.PloS one · 2012Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
P34 and P37 are two previously identified RNA binding proteins in the flagellate protozoan Trypanosoma brucei. RNA interference studies have determined that the proteins are essential and are involved in ribosome biogenesis. Here, we show that these proteins interact in vitro with the 5S rRNA with nearly identical binding characteristics in the absence of other cellular factors. The T. brucei 5S rRNA has a complex secondary structure and presents four accessible loops (A to D) for interactions with RNA-binding proteins. In other eukaryotes, loop C is bound by the L5 ribosomal protein and loop A mainly by TFIIIA. The binding of P34 and P37 to T. brucei 5S rRNA involves the LoopA region of the RNA, but these proteins also protect the L5 binding site located on LoopC.
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Registered trials
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