ArticlePloS one2012
Effect of vaccines and antivirals during the major 2009 A(H1N1) pandemic wave in Norway--and the influence of vaccination timing.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- Pandemic Preparedness Against Influenza: DNA Vaccine for Rapid Relief.Frontiers in immunology · 2021Article
- Hospitalization following influenza infection and pandemic vaccination in multiple sclerosis patients: a nationwide population-based registry study from Norway.European journal of epidemiology · 2020Article
- Burden of medically attended influenza in Norway 2008-2017.Influenza and other respiratory viruses · 2019Article
- A theoretical single-parameter model for urbanisation to study infectious disease spread and interventions.PLoS computational biology · 2019Article
- Antibody levels in a cohort of pregnant women after the 2009 influenza A(H1N1) pandemic: Waning and association with self-reported severity and duration of illness.Influenza and other respiratory viruses · 2019Article
- Evaluation of Influenza Intervention Strategies in Turkey with Fuzzy AHP-VIKOR.Journal of healthcare engineering · 2019Article
- Pandemic influenza and subsequent risk of type 1 diabetes: a nationwide cohort study.Diabetologia · 2018Article
- Encephalitis after influenza and vaccination: a nationwide population-based registry study from Norway.International journal of epidemiology · 2017Article
- H1N1 influenza virus induces narcolepsy-like sleep disruption and targets sleep-wake regulatory neurons in mice.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- An Overview of the 2009 A(H1N1) Pandemic in Europe: Efficiency of the Vaccination and Healthcare Strategies.Journal of healthcare engineering · 2016Review
- Risk of Guillain-Barré syndrome after exposure to pandemic influenza A(H1N1)pdm09 vaccination or infection: a Norwegian population-based cohort study.European journal of epidemiology · 2016Article
- Twin Peaks: A/H1N1 Pandemic Influenza Virus Infection and Vaccination in Norway, 2009-2010.PloS one · 2016Article
- Article
- Febrile seizures after 2009 influenza A (H1N1) vaccination and infection: a nationwide registry-based study.BMC infectious diseases · 2015Article
- Estimating the United States demand for influenza antivirals and the effect on severe influenza disease during a potential pandemic.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Article
- Identification of Influenza A/PR/8/34 Donor Viruses Imparting High Hemagglutinin Yields to Candidate Vaccine Viruses in Eggs.PloS one · 2015Article
- Article
- Counting pandemic deaths: comparing reported numbers of deaths from influenza A(H1N1)pdm09 with estimated excess mortality.Influenza and other respiratory viruses · 2013Article
- Vaccination strategies for future influenza pandemics: a severity-based cost effectiveness analysis.BMC infectious diseases · 2013Article
- Risk of fetal death after pandemic influenza virus infection or vaccination.The New England journal of medicine · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To evaluate the impact of mass vaccination with adjuvanted vaccines (eventually 40% population coverage) and antivirals during the 2009 influenza pandemic in Norway, we fitted an age-structured SEIR model using data on vaccinations and sales of antivirals in 2009/10 in Norway to Norwegian ILI surveillance data from 5 October 2009 to 4 January 2010. We estimate a clinical attack rate of approximately 30% (28.7-29.8%), with highest disease rates among children 0-14 years (43-44%). Vaccination started in week 43 and came too late to have a strong influence on the pandemic in Norway. Our results indicate that the countermeasures prevented approximately 11-12% of potential cases relative to an unmitigated pandemic. Vaccination was found responsible for roughly 3 in 4 of the avoided infections. An estimated 50% reduction in the clinical attack rate would have resulted from vaccination alone, had the campaign started 6 weeks earlier. Had vaccination been prioritized for children first, the intervention should have commenced approximately 5 weeks earlier in order to achieve the same 50% reduction. In comparison, we estimate that a non-adjuvanted vaccination program should have started 8 weeks earlier to lower the clinical attack rate by 50%. In conclusion, vaccination timing was a critical factor in relation to the spread of the 2009 A(H1N1) influenza. Our results also corroborate the central role of children for the transmission of A(H1N1) pandemic influenza.
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