ArticlePloS one2012
Nanomechanics and sodium permeability of endothelial surface layer modulated by hawthorn extract WS 1442.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- The potassium channel KNature communications · 2025Article
- Review
- Effects of Chronic Kidney Disease on Nanomechanics of the Endothelial Glycocalyx Are Mediated by the Mineralocorticoid Receptor.International journal of molecular sciences · 2022Article
- Hawthorn fruit acid consumption attenuates hyperlipidemia-associated oxidative damage in rats.Frontiers in nutrition · 2022Article
- Roles and Mechanisms of Hawthorn and Its Extracts on Atherosclerosis: A Review.Frontiers in pharmacology · 2020Review
- SAFETY AND EFFECTS OFActa clinica Croatica · 2019Article
- Endothelial Nanomechanics in the Context of Endothelial (Dys)function and Inflammation.Antioxidants & redox signaling · 2019Review
- Laminar shear stress modulates endothelial luminal surface stiffness in a tissue-specific manner.Microcirculation (New York, N.Y. : 1994) · 2018Article
- Benefit-Risk Assessment of Crataegus Extract WS 1442: An Evidence-Based Review.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2018Review
- Sodium selective erythrocyte glycocalyx and salt sensitivity in man.Pflugers Archiv : European journal of physiology · 2015Article
- Sodium renders endothelial cells sticky for red blood cells.Frontiers in physiology · 2015Article
- The role of ENaC in vascular endothelium.Pflugers Archiv : European journal of physiology · 2014Review
- Nanomechanics of vascular endothelium.Cell and tissue research · 2014Review
- Vascular endothelium leaves fingerprints on the surface of erythrocytes.Pflugers Archiv : European journal of physiology · 2013Article
- Determination of erythrocyte sodium sensitivity in man.Pflugers Archiv : European journal of physiology · 2013Article
- Article
- A physiological concept unmasking vascular salt sensitivity in man.Pflugers Archiv : European journal of physiology · 2012Article
- Two barriers for sodium in vascular endothelium?Annals of medicine · 2012Review
Corrections and comments
- Erratum issuedDrueppel, Verena [corrected to Drüppel, Verena]
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The endothelial glycocalyx (eGC) plays a pivotal role in the physiology of the vasculature. By binding plasma proteins, the eGC forms the endothelial surface layer (ESL) which acts as an interface between bloodstream and endothelial cell surface. The functions of the eGC include mechanosensing of blood flow induced shear stress and thus flow dependent vasodilation. There are indications that levels of plasma sodium concentrations in the upper range of normal and beyond impair flow dependent regulation of blood pressure and may therefore increase the risk for hypertension. Substances, therefore, that prevent sodium induced endothelial dysfunction may be attractive for the treatment of cardiovascular disease. By means of combined atomic force-epifluorescence microscopy we studied the impact of the hawthorn (Crataegus spp.) extract WS 1442, a herbal therapeutic with unknown mechanism of action, on the mechanics of the ESL of ex vivo murine aortae. Furthermore, we measured the impact of WS 1442 on the sodium permeability of endothelial EA.hy 926 cell monolayer. The data show that (i) the ESL contributes by about 11% to the total endothelial barrier resistance for sodium and (ii) WS 1442 strengthens the ESL resistance for sodium up to about 45%. This mechanism may explain some of the vasoprotective actions of this herbal therapeutic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.