ArticlePloS one2012
Impact of the genome wide supported NRGN gene on anterior cingulate morphology in schizophrenia.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- The association between rs12807809 polymorphism in neurogranin gene and risk of schizophrenia: A meta-analysis.Medicine · 2019Pooled it
- Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT).Molecular psychiatry · 2014Pooled it
- Effects of the neurogranin variant rs12807809 on thalamocortical morphology in schizophrenia.PloS one · 2013Trial
- Cognitive Stress Regulation in Schizophrenia Patients and Healthy Individuals: Brain and Behavior.Journal of clinical medicine · 2023Article
- Differential H3K9me2 heterochromatin levels and concordant mRNA expression in postmortem brain tissue of individuals with schizophrenia, bipolar, and controls.Frontiers in psychiatry · 2022Article
- Neurogranin, Encoded by the Schizophrenia Risk Gene NRGN, Bidirectionally Modulates Synaptic Plasticity via Calmodulin-Dependent Regulation of the Neuronal Phosphoproteome.Biological psychiatry · 2021Article
- Shaping the Trans-Scale Properties of SchizophreniaFrontiers in human neuroscience · 2021Review
- Neurogranin regulates sensorimotor gating through cortico-striatal circuitry.Neuropharmacology · 2019Article
- Association between NRGN gene polymorphism and resting-state hippocampal functional connectivity in schizophrenia.BMC psychiatry · 2019Article
- A 1.5-Year Longitudinal Study of Social Activity in Patients With Schizophrenia.Frontiers in psychiatry · 2019Article
- Cognitive clustering in schizophrenia patients, their first-degree relatives and healthy subjects is associated with anterior cingulate cortex volume.NeuroImage. Clinical · 2017Article
- Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders.Nature communications · 2016Article
- Imaging genetics and psychiatric disorders.Current molecular medicine · 2015Review
- Genetic underpinnings of white matter 'connectivity': heritability, risk, and heterogeneity in schizophrenia.Schizophrenia research · 2015Review
- Common variants at 1p36 are associated with superior frontal gyrus volume.Translational psychiatry · 2014Article
- The impact of the genome-wide supported variant in the cyclin M2 gene on gray matter morphology in schizophrenia.Behavioral and brain functions : BBF · 2013Article
- The impact of genome-wide supported schizophrenia risk variants in the neurogranin gene on brain structure and function.PloS one · 2013Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe rs12807809 single-nucleotide polymorphism in NRGN is a genetic risk variant with genome-wide significance for schizophrenia. The frequency of the T allele of rs12807809 is higher in individuals with schizophrenia than in those without the disorder. Reduced immunoreactivity of NRGN, which is expressed exclusively in the brain, has been observed in Brodmann areas (BA) 9 and 32 of the prefrontal cortex in postmortem brains from patients with schizophrenia compared with those in controls.
methodsGenotype effects of rs12807809 were investigated on gray matter (GM) and white matter (WM) volumes using magnetic resonance imaging (MRI) with a voxel-based morphometry (VBM) technique in a sample of 99 Japanese patients with schizophrenia and 263 healthy controls.
resultsAlthough significant genotype-diagnosis interaction either on GM or WM volume was not observed, there was a trend of genotype-diagnosis interaction on GM volume in the left anterior cingulate cortex (ACC). Thus, the effects of NRGN genotype on GM volume of patients with schizophrenia and healthy controls were separately investigated. In patients with schizophrenia, carriers of the risk T allele had a smaller GM volume in the left ACC (BA32) than did carriers of the non-risk C allele. Significant genotype effect on other regions of the GM or WM was not observed for either the patients or controls.
conclusionsOur findings suggest that the genome-wide associated genetic risk variant in the NRGN gene may be related to a small GM volume in the ACC in the left hemisphere in patients with schizophrenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.