ArticlePloS one2012
Modulation of the pentose phosphate pathway induces endodermal differentiation in embryonic stem cells.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Review
- The paradox of metabolism in quiescent stem cells.FEBS letters · 2019Review
- Distinct metabolic states govern skeletal muscle stem cell fates during prenatal and postnatal myogenesis.Journal of cell science · 2018Article
- Improvement of neuronal differentiation by carbon monoxide: Role of pentose phosphate pathway.Redox biology · 2018Article
- The metabolic programming of stem cells.Genes & development · 2017Review
- Metabolic remodeling during the loss and acquisition of pluripotency.Development (Cambridge, England) · 2017Review
- Stem Cell Metabolism in Cancer and Healthy Tissues: Pyruvate in the Limelight.Frontiers in pharmacology · 2017Review
- NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming.Cell reports · 2016Article
- The return of metabolism: biochemistry and physiology of the pentose phosphate pathway.Biological reviews of the Cambridge Philosophical Society · 2015Review
- Metabolic restructuring and cell fate conversion.Cellular and molecular life sciences : CMLS · 2015Review
- Dichloroacetate, the Pyruvate Dehydrogenase Complex and the Modulation of mESC Pluripotency.PloS one · 2015Article
- Differentiate or Die: 3-Bromopyruvate and Pluripotency in Mouse Embryonic Stem Cells.PloS one · 2015Article
- HTS/HCS to screen molecules able to maintain embryonic stem cell self-renewal or to induce differentiation: overview of protocols.Stem cell reviews and reports · 2014Review
- Metabolic requirements for the maintenance of self-renewing stem cells.Nature reviews. Molecular cell biology · 2014Review
- Mn porphyrin regulation of aerobic glycolysis: implications on the activation of diabetogenic immune cells.Antioxidants & redox signaling · 2013Article
- Stem cell metabolism in tissue development and aging.Development (Cambridge, England) · 2013Review
- Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal.Cell stem cell · 2012Article
- Potential of pluripotent stem cells for diabetes therapy.Current diabetes reports · 2012Review
- The proline regulatory axis and cancer.Frontiers in oncology · 2012Article
- Article
Corrections and comments
- Retraction · 2019-09-19Concerns/Issues about Data · Duplication of/in Image ·
- Retracted
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Embryonic stem (ES) cells can differentiate in vitro into a variety of cell types. Efforts to produce endodermal cell derivatives, including lung, liver and pancreas, have been met with modest success. Understanding how the endoderm originates from ES cells is the first step to generate specific cell types for therapeutic purposes. Recently, it has been demonstrated that inhibition of Myc or mTOR induces endodermal differentiation. Both Myc and mTOR are known to be activators of the Pentose Phosphate Pathway (PPP). We found that, differentely from wild type (wt), ES cells unable to produce pentose sugars through PPP differentiate into endodermal precursors in cell culture conditions generally non-permissive to generate them. The same effect was observed when wt ES cells were differentiated in presence of chemical inhibitors of the PPP. These data highlight a new role for metabolism. Indeed, to our knowledge, it is the first time that modulation of a metabolic pathway is described to be crucial in determining ES cell fate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.