ArticlePLoS medicine2012
Long-term survival in a large cohort of patients with venous thrombosis: incidence and predictors.
Article in PLoS medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01853202 (EXercise Training for the Prevention of Cancer Thrombosis), which is not on this map. Cited by 48 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
EXercise Training for the Prevention of Cancer Thrombosis (EXPECT) Pilot Trial
Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Systemic Review and Meta-Analysis of the Risk of Venous Thromboembolic Events in Parkinson's Patients.European journal of neurology · 2025Pooled it
- Current and former smoking and risk for venous thromboembolism: a systematic review and meta-analysis.PLoS medicine · 2013Pooled it
- Glucocorticoid use and risk of first and recurrent venous thromboembolism: self-controlled case-series and cohort study.British journal of haematology · 2021Trial
- Prognosis of patients with suspected pulmonary embolism in Buenos Aires: a prospective cohort study.BMC pulmonary medicine · 2014Trial
- Population Pharmacokinetic/Pharmacodynamic Analysis of HHT120, a Novel Direct Thrombin Inhibitor, in Healthy Participants from a Phase I Clinical Trial.Clinical pharmacokinetics · 2026Article
- Clinical significance of symptomatic and incidental venous thromboembolism in patients with cancer treated with apixaban.Research and practice in thrombosis and haemostasis · 2026Article
- Long-term mortality and causes of death after venous thromboembolism: findings from the Atherosclerosis Risk in Communities Cohort Study.Journal of thrombosis and haemostasis : JTH · 2026Article
- Cancer-associated venous thromboembolism and its impact on survival in the ONCOTHROMB12-01 cohort study.International journal of cardiology. Heart & vasculature · 2025Article
- Effects on mortality of extended versus short-term anticoagulation in venous thromboembolism: a systematic review and meta-analysis of randomized trials.Research and practice in thrombosis and haemostasis · 2025Article
- Gender-specific relationships between hyperuricemia and idiopathic deep venous thrombosis in the Chinese population: a case‒control study.Thrombosis journal · 2024Article
- Harnessing Artificial Neural Networks for Spinal Cord Injury Prognosis.Journal of clinical medicine · 2024Article
- In-Hospital versus Out-of-Hospital Pulmonary Embolism: Clinical Characteristics, Biochemical Markers and Echocardiographic Indices.Journal of cardiovascular development and disease · 2024Article
- Survival after cancer-related venous thrombosis: the Scandinavian Thrombosis and Cancer Study.Blood advances · 2023Article
- Coagulation factors II, V, VII, IX, X and XI and mortality - a cohort study.Research and practice in thrombosis and haemostasis · 2023Article
- Long-term mortality in patients with pulmonary embolism: results in a single-center registry.Research and practice in thrombosis and haemostasis · 2023Article
- Article
- Epidemiology and prevention of venous thromboembolism.Nature reviews. Cardiology · 2023Review
- Economic Evaluation of Direct Oral Anticoagulants Compared to Warfarin for Venous Thromboembolism in Thailand: A Cost-Utility Analysis.International journal of environmental research and public health · 2023Review
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVenous thrombosis is a common disease with a high mortality rate shortly after the event. However, details on long-term mortality in these patients are lacking. The aim of this study was to determine long-term mortality in a large cohort of patients with venous thrombosis. METHODS AND
findings4,947 patients from the Multiple Environmental and Genetic Assessment study of risk factors for venous thrombosis (MEGA study) with a first nonfatal venous thrombosis or pulmonary embolism and 6,154 control individuals without venous thrombosis, aged 18 to 70 years, were followed up for 8 years. Death and causes of death were retrieved from the Dutch death registration. Standardized mortality ratios (SMRs) were calculated for patients compared with control individuals. Several subgroups were studied as well. 736 participants (601 patients and 135 controls) died over a follow-up of 54,948 person-years. The overall mortality rate was 22.7 per 1,000 person-years (95% CI 21.0-24.6) for patients and 4.7 per 1,000 person-years (95% CI 4.0-5.6) for controls. Patients with venous thrombosis had a 4.0-fold (95% CI 3.7-4.3) increased risk of death compared with controls. The risk remained increased up to 8 years after the thrombotic event, even when no additional comorbidities were present. The highest risk of death was found for patients with additional malignancies (SMR 5.5, 95% CI 5.0-6.1). Main causes of death were diseases of the circulatory system, venous thrombosis, and malignancies. Main limitation was a maximum age of 70 at time of inclusion for the first event. Therefore results can not be generalized to those in the highest age categories.
conclusionsPatients who experienced a first venous thrombosis had an increased risk of death which lasted up to 8 years after the event, even when no comorbidities were present at time of thrombosis. Future long-term clinical follow-up could be beneficial in these patients. Please see later in the article for the Editors' Summary.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.