ArticleAmerican journal of physiology. Endocrinology and metabolism2012
Testosterone increases the muscle protein synthesis rate but does not affect very-low-density lipoprotein metabolism in obese premenopausal women.
Article in American journal of physiology. Endocrinology and metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00805207 (Sex Steroids, Sleep, and Metabolic Dysfunction in Women), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sex Steroids, Sleep, and Metabolic Dysfunction in Women
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Sex differences in the association between marital status and the risk of cardiovascular, cancer, and all-cause mortality: a systematic review and meta-analysis of 7,881,040 individuals.Global health research and policy · 2020Pooled it
- Myofibrillar Protein Synthesis Rates Do not Differ With Low and High Estradiol Concentrations Across the Menstrual Cycle.The Journal of clinical endocrinology and metabolism · 2026Trial
- Systemic delivery of estradiol, but not testosterone or progesterone, alters very low density lipoprotein-triglyceride kinetics in postmenopausal women.The Journal of clinical endocrinology and metabolism · 2014Trial
- Testosterone and progesterone, but not estradiol, stimulate muscle protein synthesis in postmenopausal women.The Journal of clinical endocrinology and metabolism · 2014Trial
- Trial
- Low-dose dexamethasone administration for 3 weeks favorably affects plasma HDL concentration and composition but does not affect very low-density lipoprotein kinetics.European journal of endocrinology · 2012Trial
- The dynamics of body composition in yellow-feathered broilers.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Understanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives.International journal of molecular sciences · 2026Review
- Sex differences in association of healthy eating pattern with all-cause mortality and cardiovascular mortality.BMC public health · 2024Article
- The Metabolic Syndrome, a Human Disease.International journal of molecular sciences · 2024Review
- Emerging Evidence of Pathological Roles of Very-Low-Density Lipoprotein (VLDL).International journal of molecular sciences · 2022Review
- Different physiological mechanisms underlie an adverse cardiovascular disease risk profile in men and women.The Proceedings of the Nutrition Society · 2020Review
- Mechanisms Underlying Metabolic Syndrome-Related Sarcopenia and Possible Therapeutic Measures.International journal of molecular sciences · 2019Review
- Activity-Based Physical Rehabilitation with Adjuvant Testosterone to Promote Neuromuscular Recovery after Spinal Cord Injury.International journal of molecular sciences · 2018Review
- Metabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesity.International journal of obesity (2005) · 2017Article
- VLDL Triglyceride Kinetics in Lean, Overweight, and Obese Men and Women.The Journal of clinical endocrinology and metabolism · 2016Article
- Plasma amino acid profiles at various reproductive stages in female rats.The Journal of veterinary medical science · 2015Article
- The Sexual Dimorphism of Lipid Kinetics in Humans.Frontiers in endocrinology · 2015Review
- The association between hyperandrogenemia and the metabolic syndrome in morbidly obese women.Diabetology & metabolic syndrome · 2015Article
- Proteomic analysis of lipid droplets from Caco-2/TC7 enterocytes identifies novel modulators of lipid secretion.PloS one · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Men and women with hyperandrogenemia have a more proatherogenic plasma lipid profile [e.g., greater triglyceride (TG) and total and low-density lipoprotein-cholesterol and lower high-density lipoprotein-cholesterol concentrations] than healthy premenopausal women. Furthermore, castration of male rats markedly reduces testosterone availability below normal and decreases plasma TG concentration, and testosterone replacement reverses this effect. Testosterone is, therefore, thought to be an important regulator of plasma lipid homeostasis. However, little is known about the effect of testosterone on plasma TG concentration and kinetics. Furthermore, testosterone is a potent skeletal muscle protein anabolic agent in men, but its effect on muscle protein turnover in women is unknown. We measured plasma lipid concentrations, hepatic very low density lipoprotein (VLDL)-TG and VLDL-apolipoprotein B-100 secretion rates, and the muscle protein fractional synthesis rate in 10 obese women before and after trandermal testosterone (1.25 g of 1% AndroGel daily) treatment for 3 wk. Serum total and free testosterone concentrations increased (P < 0.05) by approximately sevenfold in response to testosterone treatment, reaching concentrations that are comparable to those in women with hyperandrogenemia, but lower than the normal range for eugonadal men. Except for a small (∼10%) decrease in plasma high-density lipoprotein particle and cholesterol concentrations (P < 0.04), testosterone therapy had no effect on plasma lipid concentrations, lipoprotein particle sizes, and hepatic VLDL-TG and VLDL-apolipoprotein B-100 secretion rates (all P > 0.05); the muscle protein fractional synthesis rate, however, increased by ∼45% (P < 0.001). We conclude that testosterone is a potent skeletal muscle protein anabolic agent, but not an important regulator of plasma lipid homeostasis in obese women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.