ArticleACS combinatorial science2012
Build/couple/pair strategy for the synthesis of stereochemically diverse macrolactams via head-to-tail cyclization.
Article in ACS combinatorial science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Virtual screening for small-molecule pathway regulators by image-profile matching.Cell systems · 2022Article
- Aza-Oxa-Triazole Based Macrocycles with Tunable Properties: Design, Synthesis, and Bioactivity.Molecules (Basel, Switzerland) · 2022Article
- Macrocycle synthesis strategy based on step-wise "adding and reacting" three components enables screening of large combinatorial libraries.Chemical science · 2020Article
- Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal.Cell chemical biology · 2018Article
- Chemical probes and drug leads from advances in synthetic planning and methodology.Nature reviews. Drug discovery · 2018Review
- Structural and conformational determinants of macrocycle cell permeability.Nature chemical biology · 2016Article
- A Multidimensional Diversity-Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles.Angewandte Chemie (International ed. in English) · 2016Article
- Synthesis of cyclic 1,3-diols as scaffolds for spatially directed libraries.Organic & biomolecular chemistry · 2016Article
- Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Discovery of a Small-Molecule Probe for V-ATPase Function.Journal of the American Chemical Society · 2015Article
- Impact of stereospecific intramolecular hydrogen bonding on cell permeability and physicochemical properties.Journal of medicinal chemistry · 2014Article
- Synthesis of stereochemically and skeletally diverse fused ring systems from functionalized C-glycosides.The Journal of organic chemistry · 2013Article
- Macrocyclic drugs and synthetic methodologies toward macrocycles.Molecules (Basel, Switzerland) · 2013Review
- An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries.Journal of computer-aided molecular design · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
A build/couple/pair (B/C/P) strategy was employed to generate a library of 7936 stereochemically diverse 12-membered macrolactams. All 8 stereoisomers of a common linear amine precursor were elaborated to form the corresponding 8 stereoisomers of two regioisomeric macrocyclic scaffolds via head-to-tail cyclization. Subsequently, these 16 scaffolds were further diversified via capping of two amine functionalities on SynPhase Lanterns. Reagents used for solid-phase diversification were selected using a sparse matrix design strategy with the aim of maximizing coverage of chemical space while adhering to a preset range of physicochemical properties.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.