ArticleAntimicrobial agents and chemotherapy2012
Role of rifampin against Propionibacterium acnes biofilm in vitro and in an experimental foreign-body infection model.
Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 1 of them a synthesis that pooled it.
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89 citing papers in PubMed, 1 synthesis or guideline pooled it, 179 citations in OpenAlex.
- Antimicrobial Tolerance in Biofilms.Microbiology spectrum · 2015Pooled it
- Value of multiplex PCR for detection of antimicrobial resistance in samples retrieved from patients with orthopaedic infections.BMC microbiology · 2020Trial
- [Antimicrobial therapy of periprosthetic joint infection : Summary of AE guidelines (2026)].Orthopadie (Heidelberg, Germany) · 2026Review
- [Antimicrobial therapy of periprosthetic joint infection : Full version of the AE guidelines (2026)].Orthopadie (Heidelberg, Germany) · 2026Review
- Rifampicin in Osteoarticular Infections: A Comprehensive Review of Current Evidence.Antibiotics (Basel, Switzerland) · 2026Review
- Surgical relevance of a pedicled omental flap for the treatment of a recurrent giant mycotic left ventricular pseudoaneurysm: a case report and review of the literature.Journal of medical case reports · 2026Review
- Preoperative antibiotic prophylaxis in primary shoulder arthroplasty patients: a systematic review.JSES international · 2025Review
- Molecular Mechanisms of Intervertebral Disc Degeneration Induced byBioMed research international · 2025Review
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- A Literature Review of Cutibacterium Acnes: From Skin Commensal to Pathogen in Shoulder Surgery.Cureus · 2024Review
- Detection of Cutibacterium (Propionibacterium) acnes in orthopaedic surgery: serious problem or contamination?International orthopaedics · 2024Article
- Phenotypic and Genotypic Characterization ofMicroorganisms · 2023Article
- Successful Treatment ofOpen forum infectious diseases · 2023Article
- Article
- Antimicrobial treatment of patients with a periprosthetic joint infection: basic principles.Arthroplasty (London, England) · 2023Review
- Article
- Article
- Review
- Microbiological Characterization ofAntibiotics (Basel, Switzerland) · 2022Article
29 more citing papers are in PubMed but not listed here.
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5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Propionibacterium acnes is an important cause of orthopedic-implant-associated infections, for which the optimal treatment has not yet been determined. We investigated the activity of rifampin, alone and in combination, against planktonic and biofilm P. acnes in vitro and in a foreign-body infection model. The MIC and the minimal bactericidal concentration (MBC) were 0.007 and 4 μg/ml for rifampin, 1 and 4 μg/ml for daptomycin, 1 and 8 μg/ml for vancomycin, 1 and 2 μg/ml for levofloxacin, 0.03 and 16 μg/ml for penicillin G, 0.125 and 512 μg/ml for clindamycin, and 0.25 and 32 μg/ml for ceftriaxone. The P. acnes minimal biofilm eradication concentration (MBEC) was 16 μg/ml for rifampin; 32 μg/ml for penicillin G; 64 μg/ml for daptomycin and ceftriaxone; and ≥128 μg/ml for levofloxacin, vancomycin, and clindamycin. In the animal model, implants were infected by injection of 10⁹ CFU P. acnes in cages. Antimicrobial activity on P. acnes was investigated in the cage fluid (planktonic form) and on explanted cages (biofilm form). The cure rates were 4% for daptomycin, 17% for vancomycin, 0% for levofloxacin, and 36% for rifampin. Rifampin cured 63% of the infected cages in combination with daptomycin, 46% with vancomycin, and 25% with levofloxacin. While all tested antimicrobials showed good activity against planktonic P. acnes, for eradication of biofilms, rifampin was needed. In combination with rifampin, daptomycin showed higher cure rates than with vancomycin in this foreign-body infection model.
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