ArticleAntimicrobial agents and chemotherapy2012
The natural antimicrobial peptide subtilosin acts synergistically with glycerol monolaurate, lauric arginate, and ε-poly-L-lysine against bacterial vaginosis-associated pathogens but not human lactobacilli.
Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Genomic and functional landscape of antimicrobial peptides and lipopeptides from ginger honey-derived Bacillus subtilis.Molecular genetics and genomics : MGG · 2026Article
- Natural Molecules, Nutraceuticals, and Engineered Nanosystems: A Comprehensive Strategy for CombatingMicroorganisms · 2025Review
- Antimicrobial Effects of Sophora flavescens Alkaloids on Metronidazole-Resistant Gardnerella vaginalis in Planktonic and Biofilm Conditions.Current microbiology · 2023Article
- Glycerol monolaurate ameliorates DSS-induced acute colitis by inhibiting infiltration of Th17, neutrophils, macrophages and altering the gut microbiota.Frontiers in nutrition · 2022Article
- Antimicrobial Activity of Bacillus subtilis KATMIRA1933 and Bacillus amyloliquefaciens B-1895 Against Staphylococcus aureus Biofilms Isolated from Wound Infection.Probiotics and antimicrobial proteins · 2021Article
- Potential Probiotics Bacillus subtilis KATMIRA1933 and Bacillus amyloliquefaciens B-1895 Co-Aggregate with Clinical Isolates of Proteus mirabilis and Prevent Biofilm Formation.Probiotics and antimicrobial proteins · 2020Article
- Anti-Biofilm Properties ofMicroorganisms · 2020Article
- Comparative Evaluation of Combinatory Interaction between Endocannabinoid System Compounds and Poly-L-lysine againstBioMed research international · 2020Article
- Glycerol monolaurate nanocapsules for biomedical applications: in vitro toxicological studies.Naunyn-Schmiedeberg's archives of pharmacology · 2019Article
- A Novel Mathematical Model for Studying Antimicrobial Interactions AgainstFrontiers in microbiology · 2019Article
- Subtilosin Prevents Biofilm Formation by Inhibiting Bacterial Quorum Sensing.Probiotics and antimicrobial proteins · 2017Article
- Protective Microbiota: From Localized to Long-Reaching Co-Immunity.Frontiers in immunology · 2017Review
- Bacteriocin-Antimicrobial Synergy: A Medical and Food Perspective.Frontiers in microbiology · 2017Review
- The Natural Antimicrobial Subtilosin A Synergizes with Lauramide Arginine Ethyl Ester (LAE), ε-Poly-L-lysine (Polylysine), Clindamycin Phosphate and Metronidazole, Against the Vaginal Pathogen Gardnerella vaginalis.Probiotics and antimicrobial proteins · 2015Article
- Bacterial Vaginosis Biofilms: Challenges to Current Therapies and Emerging Solutions.Frontiers in microbiology · 2015Review
- Antibacterial synergy of glycerol monolaurate and aminoglycosides in Staphylococcus aureus biofilms.Antimicrobial agents and chemotherapy · 2014Article
- Antiherpes simplex virus type 2 activity of the antimicrobial peptide subtilosin.Journal of applied microbiology · 2014Article
- Polyethylene glycol-based hydrogels for controlled release of the antimicrobial subtilosin for prophylaxis of bacterial vaginosis.Antimicrobial agents and chemotherapy · 2014Article
- Anti-infective properties of bacteriocins: an update.Cellular and molecular life sciences : CMLS · 2013Review
- Bacteriocins - a viable alternative to antibiotics?Nature reviews. Microbiology · 2013Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Subtilosin is a cyclical antimicrobial peptide produced by Bacillus amyloliquefaciens that has antimicrobial activity against the bacterial vaginosis-associated human pathogen Gardnerella vaginalis. The ability of subtilosin to inhibit G. vaginalis alone and in combination with the natural antimicrobial agents glycerol monolaurate (Lauricidin), lauric arginate, and ε-poly-L-lysine was tested using a checkerboard approach. Subtilosin was found to act synergistically with all of the chosen antimicrobials. These promising results indicate that lower concentrations of subtilosin in combination with other compounds could effectively be used to inhibit growth of the pathogen, thereby decreasing the risk of developed antimicrobial resistance. This is the first report on the effects of subtilosin combined with other natural antimicrobials against G. vaginalis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.