Evidence map›Paper›PMID 22252677›Full record

ArticleCancer causes & control : CCC2012

Racial variation in umbilical cord blood sex steroid hormones and the insulin-like growth factor axis in African-American and white female neonates.

Tanya Agurs-Collins, Sabine Rohrmann, Catherine Sutcliffe, Jessica L Bienstock, Deborah Monsegue, Folasade Akereyeni, Gary Bradwin, Nader Rifai, Michael N Pollak, Elizabeth A Platz

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Tanya Agurs-CollinsDivision of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA. collinsta@mail.nih.gov
Sabine Rohrmann
Catherine Sutcliffe
Jessica L Bienstock
Deborah Monsegue
Folasade Akereyeni
Gary Bradwin
Nader Rifai
Michael N Pollak
Elizabeth A Platz
Boston Children's Hospital · USHoward University · USJohns Hopkins University · USJewish General Hospital · CAJohns Hopkins Medicine · USNational Cancer Institute · USUniversity of Zurich · CH

Funding

Resources and Infrastructure: Faculty RecruitmentU54CA091431 · NCI · HOWARD UNIVERSITY · PI SMOOT, DUANE T. · 2001 to 2010
$15.9M
Synthesis and MAPK Kinase Inhibitiory Activities in Prostate TumorsU54CA091409 · NCI · JOHNS HOPKINS UNIVERSITY · PI COFFEY, DONALD STRALEY · 2001 to 2010
$8.9M
Intramural NIH HHS Z99 CA999999NCI NIH HHS U54 CA091409NCI NIH HHS U54 CA091431NCI NIH HHS Y99 CA999999
6 · The paper itself

Abstract

purposeTo evaluate whether there is racial variation in venous umbilical cord blood concentrations of sex steroid hormones and the insulin-like growth factor (IGF) axis between female African-American and white neonates.

methodsMaternal and birth characteristics and venous umbilical cord blood samples were collected from 77 African-American and 41 white full-term uncomplicated births at two urban hospitals in 2004 and 2005. Cord blood was measured for testosterone, dehydroespiandrosterone-sulfate, estradiol, and sex steroid hormone-binding globulin (SHBG) by immunoassay. IGF-1, IGF-2, and IGF-binding protein-3 (IGFBP-3) were measured by ELISA. Crude and multivariable-adjusted geometric mean concentrations were computed for the hormones.

resultsAfrican-American neonates weighed less at birth (3,228 g vs. 3,424 g, p < 0.004) than whites. Birth weight was positively correlated with IGF-1, IGFBP-3, and the molar ratio of IGF-1 to IGFBP-3, but inversely correlated with the molar ratio of IGF-2 to IGFBP-3. Adjusted models showed higher testosterone (1.82 ng/ml vs. 1.47 ng/ml, p = 0.006) and the molar ratio of testosterone to SHBG (0.42 vs. 0.30, p = 0.03) in African-American compared to white female neonates. IGF-1, IGF-2, and IGFBP-3 were lower in African-American compared to white female neonates, but only the difference for IGF-2 remained significant (496.5 ng/ml vs. 539.2 ng/ml, p = 0.04).

conclusionWe provide evidence of racial variation in cord blood testosterone and testosterone to SHBG in African-American compared to white female neonates, and higher IGF-2 in white compared to African-American female neonates. Findings suggest plausible explanations for a prenatal influence on subsequent breast cancer risk and mortality. Further work is needed to confirm these observations.

Indexed as

Black or African AmericanWhite PeopleEnzyme-Linked Immunosorbent AssayEstradiolFemaleFetal BloodGonadal Steroid HormonesHumansInfant, NewbornInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IInsulin-Like Growth Factor IIMultivariate AnalysisPilot ProjectsSex FactorsSex Hormone-Binding GlobulinEstradiolGonadal Steroid HormonesInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IInsulin-Like Growth Factor IISex Hormone-Binding GlobulinTestosterone

Identifiers

PMID22252677
PMCPMC3333795
OpenAlexW2041024451

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.