Evidence map›Paper›PMID 22252455›Full record

ArticlePhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2012

Externally sensitized deprotection of PPG-masked carbonyls as a spatial proximity probe in photoamplified detection of binding events.

Tiffany P Gustafson, Greg A Metzel, Andrei G Kutateladze

Abstract read
In one paragraph

Article in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Photoactive Spatial Proximity Probes for Binding Pairs with Epigenetic Marks.Journal of photochemistry and photobiology. A, Chemistry · 2014
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tiffany P GustafsonDepartment of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, USA.
Greg A Metzel
Andrei G Kutateladze

Funding

Ultrasensitive Photoamplifed Fluorescence Detection of Ligand Binding on a ChipR21EB008532 · NIBIB · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI KUTATELADZE, ANDREI G · 2008 to 2009
$409k
NIBIB NIH HHS R21 EB008532
6 · The paper itself

Abstract

Externally sensitized electron-transfer fragmentation in dithiane PPG (photoremovable protecting group)-protected carbonyls is adopted for detection and amplification of molecular recognition events. The new methodology allows for detection of as low as 50 attomoles of avidin utilizing an imager based on a low sensitivity mass-produced consumer CCD camera. Numeric modelling is carried out to demonstrate the intrinsic limitations of 2D amplification on surfaces and the advantages of unconstrained amplification in a compartmentalized volume of spatially addressable 3D solutions.

Indexed as

BenzophenonesBinding SitesComputer SimulationFluorescent DyesQuinolizinesSulfur CompoundsBenzophenonesdithianeFluorescent DyesQuinolizinesSulfur Compounds

Identifiers

PMID22252455
PMCPMC3755620

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.