ArticleMolecular systems biology2012
Bistability in feedback circuits as a byproduct of evolution of evolvability.
Article in Molecular systems biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 35 citations in OpenAlex.
- Bayesian inference of gene regulatory networks at stochastic steady state.Journal of the Royal Society, Interface · 2026Article
- Bayesian Inference of Gene Regulatory Networks at Stochastic Steady State.bioRxiv : the preprint server for biology · 2026Article
- Critical-like Brain Dynamics in a Continuum from Second- to First-Order Phase Transition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Epigenetic switching as a strategy for quick adaptation while attenuating biochemical noise.PLoS computational biology · 2019Article
- Evolution of evolvability and phenotypic plasticity in virtual cells.BMC evolutionary biology · 2017Article
- Switch-like Transitions Insulate Network Motifs to Modularize Biological Networks.Cell systems · 2016Article
- Enzyme Sequestration as a Tuning Point in Controlling Response Dynamics of Signalling Networks.PLoS computational biology · 2016Article
- Nonlinear Dynamics in Gene Regulation Promote Robustness and Evolvability of Gene Expression Levels.PloS one · 2016Article
- ComGA-RelA interaction and persistence in the Bacillus subtilis K-state.Molecular microbiology · 2015Article
- A Philosophical Perspective on Evolutionary Systems Biology.Biological theory · 2015Article
- The details in the distributions: why and how to study phenotypic variability.Current opinion in biotechnology · 2013Article
- Single-cell phenomics reveals intra-species variation of phenotypic noise in yeast.BMC systems biology · 2013Article
- Noise induced oscillations and coherence resonance in a generic model of the nonisothermal chemical oscillator.Scientific reports · 2013Article
- Toxin-antitoxin genes of the Gram-positive pathogen Streptococcus pneumoniae: so few and yet so many.Microbiology and molecular biology reviews : MMBR · 2012Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Noisy bistable dynamics in gene regulation can underlie stochastic switching and is demonstrated to be beneficial under fluctuating environments. It is not known, however, if fluctuating selection alone can result in bistable dynamics. Using a stochastic model of simple feedback networks, we apply fluctuating selection on gene expression and run in silico evolutionary simulations. We find that independent of the specific nature of the environment-fitness relationship, the main outcome of fluctuating selection is the evolution of increased evolvability in the network; system parameters evolve toward a nonlinear regime where phenotypic diversity is increased and small changes in genotype cause large changes in expression level. In the presence of noise, the evolution of increased nonlinearity results in the emergence and maintenance of bistability. Our results provide the first direct evidence that bistability and stochastic switching in a gene regulatory network can emerge as a mechanism to cope with fluctuating environments. They strongly suggest that such emergence occurs as a byproduct of evolution of evolvability and exploitation of noise by evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.