ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2012
Endocrine carcinoma of the stomach: clinicopathological analysis of 27 surgically treated cases in a single institute.
Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed.
- Early Liver Metastasis from Early Gastric Adenocarcinoma with a Small Neuroendocrine Carcinoma Component: A Case Report.Surgical case reports · 2025Article
- A Case of Gastric Neuroendocrine Carcinoma with Disseminated Recurrence 14 Years after Initial Surgery.Surgical case reports · 2025Article
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- Clinicopathological characteristics of gastric neuroendocrine neoplasms: A comprehensive analysis.Cancer medicine · 2024Article
- Artificial Intelligence Model for a Distinction between Early-Stage Gastric Cancer Invasive Depth T1a and T1b.Journal of Cancer · 2024Article
- Better Prognosis of Gastric Neuroendocrine Carcinoma Than Gastric Adenocarcinoma among Whites in the United States: A Propensity Score Matching Analysis Based on SEER.Current oncology (Toronto, Ont.) · 2022Article
- Comparison of Survival and Patterns of Recurrence in Gastric Neuroendocrine Carcinoma, Mixed Adenoneuroendocrine Carcinoma, and Adenocarcinoma.JAMA network open · 2021Article
- Gastric Neuroendocrine Carcinoma with Rapid Progression.Internal medicine (Tokyo, Japan) · 2020Article
- Treatment strategies for neuroendocrine carcinoma of the upper digestive tract.International journal of clinical oncology · 2020Article
- Clinical characteristics of early neuroendocrine carcinoma in stomach: A case report and review of literature.Medicine · 2019Article
- Gastric mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) with pancreatic acinar differentiation: a case report.Diagnostic pathology · 2019Article
- The Significant Influence of the Neuroendocrine Component on the Survival of Patients with Gastric Carcinoma Characterized by Coexisting Exocrine and Neuroendocrine Components.Journal of oncology · 2019Article
- Nomogram based on tumor-associated neutrophil-to-lymphocyte ratio to predict survival of patients with gastric neuroendocrine neoplasms.World journal of gastroenterology · 2017Article
- Different long-term oncologic outcomes after radical surgical resection for neuroendocrine carcinoma and adenocarcinoma of the stomach.Oncotarget · 2017Article
- Comparison of relapse-free survival in gastric neuroendocrine carcinoma (WHO grade 3) and gastric carcinoma.Therapeutic advances in gastroenterology · 2017Article
- Sporadic Gastric Well-Differentiated Neuroendocrine Tumors Have a Higher Ki-67 Proliferative Index.Endocrine pathology · 2016Article
- Article
- A resected case of neuroendocrine carcinoma of the stomach with unusual lymph node metastasis.Medical molecular morphology · 2016Article
- [Association of neuroendocrine differentiation with progression and prognosis of gastric adenocarcinoma].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2016Article
- Histological characterisation and prognostic evaluation of 62 gastric neuroendocrine carcinomas.Contemporary oncology (Poznan, Poland) · 2016Article
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6 authors.
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Abstract
backgroundGastric endocrine carcinoma (EC) is an uncommon tumor of the stomach and the clinical features are not well known. Additionally, the classification and staging systems of this tumor are not yet unified worldwide. In this study, we reviewed 27 patients with gastric EC to evaluate the clinicopathological characteristics of this tumor.
methodsWe retrospectively reviewed 27 patients with gastric EC among 6466 patients who had undergone gastrectomy between 1986 and 2008 at our institute. Clinicopathological features including immunohistochemistry of Ki-67 were investigated to evaluate the malignant potential of the tumor. Furthermore, survivals were compared between the 7th edition of the International Union Against Cancer (UICC)-TNM (7th TNM) classification for gastric cancer (GC) and the new TNM classification for foregut neuroendocrine tumors (NET).
resultsThe median survival of the patients was 19.0 months. The 5-year survival rate was 100% in pathological stage (pStage) I, 40% in pStage II, 38% in pStage III, and 11% in pStage IV according to the 7th TNM classification for GC. Survivals by stage showed great difference between the 7th TNM classification for GC and the new TNM classification for foregut NET, but each system correlated with survival. The Ki-67 labeling index was more than 20% in most of the patients. Univariate analysis revealed that maximum tumor diameter, tumor depth, lymph node metastasis, lymphatic invasion, pStage, and curability had significant correlations with survival.
conclusionEarly detection and curative operations are essential for improving the prognosis of gastric EC. However, some adjuvant chemotherapies are required for advanced-stage tumors. Classification and staging systems may need to be unified worldwide for further analysis.
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