ReviewMolecular aspects of medicine
The role of renal water channels in health and disease.
Review in Molecular aspects of medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 41 citations in OpenAlex.
- Effect of transporter and DNA repair gene polymorphisms to lung cancer chemotherapy toxicity.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Trial
- Garlic Improves Normal Water and Sodium Handling in Diabetic Kidneys by Attenuating Atrial Natriuretic Peptide: A Comparison with Metformin Treatment.International journal of molecular sciences · 2026Article
- Expression of aquaporin 3 in squamous cell carcinoma in dogs and cats.The Journal of veterinary medical science · 2026Article
- Assessing the Role of Aquaporin 4 in Skeletal Muscle Function.International journal of molecular sciences · 2023Review
- Comparative quantitation of aquaporin-2 and arginine vasopressin receptor-2 localizations among chronic kidney disease and healthy kidney in dogs.Veterinary world · 2021Article
- Organ Specific Differences in Alteration of Aquaporin Expression in Rats Treated with Sennoside A, Senna Anthraquinones and Rhubarb Anthraquinones.International journal of molecular sciences · 2021Article
- Anti-Malignant Ascites Effect of Total Diterpenoids fromMolecules (Basel, Switzerland) · 2021Article
- Vitamin D Regulates the Expressions of AQP-1 and AQP-4 in Mice Kidneys.BioMed research international · 2019Article
- Aquaporin-graphene interface: relevance to point-of-care device for renal cell carcinoma and desalination.Interface focus · 2018Review
- Resistin, a fat-derived secretory factor, promotes metastasis of MDA-MB-231 human breast cancer cells through ERM activation.Scientific reports · 2016Article
- Ontogeny of the mammalian kidney: expression of aquaporins 1, 2, 3, and 4.World journal of pediatrics : WJP · 2014Review
- Down-regulated aquaporin 5 inhibits proliferation and migration of human epithelial ovarian cancer 3AO cells.Journal of ovarian research · 2014Article
- Brown Norway chromosome 1 congenic reduces symptoms of renal disease in fatty Zucker rats.PloS one · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Seven members of the aquaporin (AQP) family are expressed in different regions of the kidney. AQP1-4 are localized in plasma membranes of renal epithelial cells and are intimately involved in water reabsorption by the kidney. AQP7 is also localized in the plasma membrane and may facilitate glycerol transport. AQP6 and AQP11 are localized within the cell, with AQP6 involved in anion transport and AQP11 water transport. Mutations in AQP2 can result in diabetes insipidus, whereas mutations in other AQPs have not yet been shown to be disease-associated. Genetic polymorphisms may contribute to the susceptibility to defects in urine concentrating mechanisms associated with some diseases. Most of the AQPs are subject to transcriptional regulation and post-translational modifications by a range of biological modifiers. As a result a number of chronic kidney and systemic diseases produce changes in the abundance of AQPs. The more recent developments in this field are reviewed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.