ReviewNature reviews. Neuroscience2012
Activity-dependent neurotransmitter respecification.
Review in Nature reviews. Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of acupuncture in animal models of vascular dementia: A systematic review and network meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- Toward a biologically grounded understanding of autonomic function in developmental science.Neuroscience and biobehavioral reviews · 2026Review
- Restoration of gamma-aminobutyric acid homeostasis: A novel approach to alleviating central nervous system injury-associated immunodepression syndrome.Neural regeneration research · 2026Article
- Developmental Neurotoxicity of Alcohol from Neuronal Basis to Behavioural Outcomes: A Comprehensive Review.Neurology international · 2026Review
- A Novel Relationship between Corticotropin-Releasing Hormone Level and High-Altitude Hypoxia in Human and Rat Model.Neuroendocrinology · 2026Article
- DRN-SNc serotonergic circuit drives stress-induced motor deficits and Parkinson's disease vulnerability.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- A Neuransistor with Excitatory and Inhibitory Neuronal Behaviors for Liquid State Machine.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Opioid-induced neuroanatomical, microglial and behavioral changes are blocked by suvorexant without diminishing opioid analgesia.Nature. Mental health · 2024Article
- Embryonic exposure to environmental factors drives transmitter switching in the neonatal mouse cortex causing autistic-like adult behavior.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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- Article
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- Cortical activity emerges in region-specific patterns during early brain development.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cortical activity emerges in region-specific patterns during early brain development.bioRxiv : the preprint server for biology · 2023Article
- Optically modulated ionic conductivity in a hydrogel for emulating synaptic functions.Science advances · 2023Article
- Molecular docking analysis of acetylcholinesterase inhibitors for Alzheimer's disease management.Bioinformation · 2023Article
- A conserved transcriptional fingerprint of multi-neurotransmitter neurons necessary for social behavior.BMC genomics · 2022Article
- Review
- High-frequency stimulation of the subthalamic nucleus induces a sustained inhibition of serotonergic system via loss of cell phenotype.Scientific reports · 2022Article
- Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
For many years it has been assumed that the identity of the transmitters expressed by neurons is stable and unchanging. Recent work, however, shows that electrical activity can respecify neurotransmitter expression during development and in the mature nervous system, and an understanding is emerging of the molecular mechanisms underlying activity-dependent transmitter respecification. Changes in postsynaptic neurotransmitter receptor expression accompany and match changes in transmitter specification, thus enabling synaptic transmission. The functional roles of neurotransmitter respecification are beginning to be understood and appear to involve homeostatic synaptic regulation, which in turn influences behaviour. Activation of this novel form of plasticity by sensorimotor stimuli may provide clinical benefits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.