Evidence map›Paper›PMID 22251872›Full record

ReviewNature reviews. Genetics2012

Protein-RNA interactions: new genomic technologies and perspectives.

Julian König, Kathi Zarnack, Nicholas M Luscombe, Jernej Ule

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 210 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
210citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

210 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
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  9. Article
  10. Structure-based insights into fluorogenic RNA aptamers.Acta biochimica et biophysica Sinica · 2024
    Review
  11. Article
  12. AdvancingPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  13. Article
  14. Article
  15. Technologies to Study Genetics and Molecular Pathways.Advances in experimental medicine and biology · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. PAR-CLIP Assay in Ferroptosis.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  20. Role of the RNA-binding protein family in gynecologic cancers.American journal of cancer research · 2023
    Review

150 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

4 authors.

Julian KönigMedical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.
Kathi Zarnack
Nicholas M Luscombe
Jernej Ule

Funding

European Research Council 206726Medical Research Council MC_U105185858Wellcome Trust 089701
6 · The paper itself

Abstract

RNA-binding proteins are key players in the regulation of gene expression. In this Progress article, we discuss state-of-the-art technologies that can be used to study individual RNA-binding proteins or large complexes such as the ribosome. We also describe how these approaches can be used to study interactions with different types of RNAs, including nascent transcripts, mRNAs, microRNAs and ribosomal RNAs, in order to investigate transcription, RNA processing and translation. Finally, we highlight current challenges in data analysis and the future steps that are needed to obtain a quantitative and high-resolution picture of protein-RNA interactions on a genome-wide scale.

Indexed as

AnimalsComputational BiologyGenomicsHigh-Throughput Nucleotide SequencingHumansRibonucleoproteinsRNARNA-Binding ProteinsRibonucleoproteinsRNARNA-Binding Proteins

Identifiers

PMID22251872

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.