ArticleProgress in neuro-psychopharmacology & biological psychiatry2012
Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology.
Article in Progress in neuro-psychopharmacology & biological psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 119 citations in OpenAlex.
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- The magic of mushrooms: psilocybin influences behavior in the mangrove rivulus fish,Frontiers in behavioral neuroscience · 2026Article
- Exploring the impact of acute solvent exposure on larval zebrafish behaviour.Frontiers in behavioral neuroscience · 2025Article
- Neurobiology of psilocybin: a comprehensive overview and comparative analysis of experimental models.Frontiers in systems neuroscience · 2025Review
- Early impact of domestication on aggressiveness, activity, and stress behaviors in zebrafish (Danio rerio) using mirror test and automated videotracking.Scientific reports · 2024Article
- Acute clomipramine exposure elicits dose-dependent surfacing behavior in adult zebrafish (PeerJ · 2024Article
- A Novel Laser-Based Zebrafish Model for Studying Traumatic Brain Injury and Its Molecular Targets.Pharmaceutics · 2022Article
- Glutamate NMDA Receptor Antagonists with Relevance to Schizophrenia: A Review of Zebrafish Behavioral Studies.Current neuropharmacology · 2022Review
- The epidemiology of mescaline use: Pattern of use, motivations for consumption, and perceived consequences, benefits, and acute and enduring subjective effects.Journal of psychopharmacology (Oxford, England) · 2022Article
- Zebrafish Modeling of Autism Spectrum Disorders, Current Status and Future Prospective.Frontiers in psychiatry · 2022Review
- Article
- THC-induced behavioral stereotypy in zebrafish as a model of psychosis-like behavior.Scientific reports · 2021Article
- Resveratrol Alleviates 27-Hydroxycholesterol-Induced Senescence in Nerve Cells and Affects Zebrafish Locomotor Behavior via Activation of SIRT1-Mediated STAT3 Signaling.Oxidative medicine and cellular longevity · 2021Article
- Zebrafish andToxicology reports · 2021Article
- Chronic phencyclidine treatment impairs spatial working memory in rhesus monkeys.Psychopharmacology · 2019Article
- Acrylamide acute neurotoxicity in adult zebrafish.Scientific reports · 2018Article
- Zebrafish: an emerging real-time model system to study Alzheimer's disease and neurospecific drug discovery.Cell death discovery · 2018Article
- Assessing the Value of the Zebrafish Conditioned Place Preference Model for Predicting Human Abuse Potential.The Journal of pharmacology and experimental therapeutics · 2017Article
- The common neural parasite Pseudoloma neurophilia causes altered shoaling behaviour in adult laboratory zebrafish (Danio rerio) and its implications for neurobehavioural research.Journal of fish diseases · 2017Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Mescaline and phencyclidine (PCP) are potent hallucinogenic agents affecting human and animal behavior. As their psychotropic effects remain poorly understood, further research is necessary to characterize phenotypes they evoke in various animal models. Zebrafish (Danio rerio) are rapidly emerging as a new model organism for neuroscience research. Here, we examine the effects of mescaline (5-20mg/l) and PCP (0.5-3mg/l) in several zebrafish paradigms, including the novel tank, open field and shoaling tests. Mescaline and PCP dose-dependently increased top activity in the novel tank test, also reducing immobility and disrupting the patterning of zebrafish swimming, as assessed by ethograms. PCP, but not mescaline, evoked circling behavior in the open field test. At the highest doses tested, mescaline markedly increased, while PCP did not affect, zebrafish shoaling behavior. Finally, 20mg/l mescaline did not alter, and 3mg/l PCP elevated, whole-body cortisol levels. Overall, our studies indicate high sensitivity of zebrafish models to hallucinogenic compounds with complex behavioral and physiological effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.