ArticleLangmuir : the ACS journal of surfaces and colloids2012
One-step fabrication of polymeric Janus nanoparticles for drug delivery.
Article in Langmuir : the ACS journal of surfaces and colloids, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Janus Nanoparticles in Doxorubicin Delivery: A New Frontier in Targeted Cancer Treatment.Materials (Basel, Switzerland) · 2026Review
- Precise nanoscale fabrication technologies, the "last mile" of medicinal development.Acta pharmaceutica Sinica. B · 2025Review
- First principles design of two dimensional TiSSe Janus drug delivery system for nitrosourea.RSC advances · 2024Article
- Target-Specific Delivery and Bioavailability of Pharmaceuticals via Janus and Dendrimer Particles.Pharmaceutics · 2023Review
- Dual-Drug Delivery by Anisotropic and Uniform Hybrid Nanostructures: A Comparative Study of the Function and Substrate-Drug Interaction Properties.Pharmaceutics · 2023Review
- Development of Janus Particles as Potential Drug Delivery Systems for Diabetes Treatment and Antimicrobial Applications.Pharmaceutics · 2023Review
- Recent advancements in Janus nanoparticle-based biosensing platforms.International nano letters · 2023Review
- Synergistically Enhancing the Therapeutic Effect on Cancer, via Asymmetric Bioinspired Materials.Molecules (Basel, Switzerland) · 2022Review
- Application of Janus Particles in Point-of-Care Testing.Biosensors · 2022Review
- Janus Droplet Formation via Thermally Induced Phase Separation: A Numerical Model with Diffusion and Convection.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Craft of Co-encapsulation in Nanomedicine: A Struggle To Achieve Synergy through Reciprocity.ACS pharmacology & translational science · 2022Review
- Microfluidic Applications in Drug Development: Fabrication of Drug Carriers and Drug Toxicity Screening.Micromachines · 2022Review
- Microfluidic Methods in Janus Particle Synthesis.International journal of nanomedicine · 2022Review
- Janus Particles at Fluid Interfaces: Stability and Interfacial Rheology.Nanomaterials (Basel, Switzerland) · 2021Review
- Disease diagnostics using hydrodynamic flow focusing in microfluidic devices: Beyond flow cytometry.Biomedical engineering letters · 2020Review
- Dual drug-loaded biodegradable Janus particles for simultaneous co-delivery of hydrophobic and hydrophilic compounds.Experimental biology and medicine (Maywood, N.J.) · 2019Article
- Magneto-thermochromic coupling Janus sphere for dual response display.RSC advances · 2019Article
- Shaping Silica Rods by Tuning Hydrolysis and Condensation of Silica Precursors.Chemistry of materials : a publication of the American Chemical Society · 2019Article
- Microfluidic assisted synthesis of PLGA drug delivery systems.RSC advances · 2019Review
- Janus particles: recent advances in the biomedical applications.International journal of nanomedicine · 2019Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
With its unique structure of two compartments, Janus particles can be used for many applications for which monomorphic particles are inadequate, including to be used as a drug delivery system to deliver multiple payloads with widely different solubility. Here we report on a fluidic nanoprecipitation system (FNPS), capable of fabricating biocompatible Janus polymeric nanoparticles comprised of the FDA-approved polymer poly(lactic-co-glycolic acid) (PLGA). The FNPS contains dual inlets, one for each half of the particle, that insert into the precipitation stream. The system provides a one-step approach for production of Janus polymeric particles with submicrometer diameters and is likely amenable to substantial scale-up. To the best of our knowledge, this is the first demonstration of biocompatible Janus nanoparticles that encapsulate a hydrophobic drug (paclitaxel) on one side and a hydrophilic drug (doxorubicin hydrochloride) on the other.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.