ArticleBJOG : an international journal of obstetrics and gynaecology2012
Maternal sepsis: a Scottish population-based case-control study.
Article in BJOG : an international journal of obstetrics and gynaecology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04621539 (Validation of the Quick Sequential [Sepsis-related] Organ Failure Assessment), which is not on this map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Validation of the Quick Sequential [Sepsis-related] Organ Failure Assessment (qSOFA) Predictive Model in the Prediction of Severe Infection - Sepsis in Obstetric Patients and Adverse Neonatal Outcomes: a Multicenter Study
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.
- Maternal Disease With Group B Streptococcus and Serotype Distribution Worldwide: Systematic Review and Meta-analyses.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Pooled it
- Cefazolin versus placebo for surgical antibiotic prophylaxis in low-risk cesarean delivery: a feasibility blinded randomized controlled trial.BMC pregnancy and childbirth · 2025Trial
- Prophylactic antibiotics in the prevention of infection after operative vaginal delivery (ANODE): a multicentre randomised controlled trial.Lancet (London, England) · 2019Trial
- Trial
- Global burden, projections, and causal factors of maternal sepsis and other maternal infections: A comprehensive epidemiological and mendelian randomization study.PLoS neglected tropical diseases · 2026Article
- The association between different aspects of socioeconomic deprivation and severe maternal morbidity.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Determinants of puerperal sepsis among postpartum women at public hospital in Gedeo Zone, southern Ethiopia, 2023: unmatched case-control study.BMC pregnancy and childbirth · 2026Article
- Burden and trend of maternal sepsis and other maternal infections in BRICS countries from 1990 to 2021.BMC pregnancy and childbirth · 2025Article
- Determinants of puerperal sepsis among postpartum women admitted to Harar town public hospitals in eastern Ethiopia: an unmatched case-control study.BMC women's health · 2025Article
- Maternal Sepsis and associated factors: A multi-central study from two tertiary care hospitals of South Punjab, Pakistan.Pakistan journal of medical sciences · 2025Article
- Risk factors for maternal pyrexia, infection and sepsis in four hospitals providing maternity care in New South Wales, Australia: a cohort study.Frontiers in global women's health · 2025Article
- Preoperative platelet distribution width predicts bone metastasis in patients with breast cancer.BMC cancer · 2024Article
- Associations between maternal bacteremia during the peripartum period and early-onset neonatal sepsis: a retrospective cohort study.BMC pediatrics · 2024Article
- Determinants of puerperal sepsis among postpartum women at a tertiary care hospital in Ethiopia: an unmatched case-control study.Contraception and reproductive medicine · 2024Article
- Obstetric infections and clinical characteristics of maternal sepsis: a hospital-based retrospective cohort study.Scientific reports · 2024Article
- Aetiology and use of antibiotics in pregnancy-related infections: results of the WHO Global Maternal Sepsis Study (GLOSS), 1-week inception cohort.Annals of clinical microbiology and antimicrobials · 2024Article
- Trends and predictions of maternal sepsis and other maternal infections among women of childbearing age: a systematic analysis for the global burden of disease study 2019.Frontiers in public health · 2024Article
- State of the art: Intrapartum antibiotics in cesarean section, the infant microbiota and allergic diseases.Acta obstetricia et gynecologica Scandinavica · 2023Review
- Exploring the Causality Between Body Mass Index and Sepsis: A Two-Sample Mendelian Randomization Study.International journal of public health · 2023Article
- Maternal Sepsis in Italy: A Prospective, Population-Based Cohort and Nested Case-Control Study.Microorganisms · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo describe the risk of maternal sepsis associated with obesity and other understudied risk factors such as operative vaginal delivery.
designPopulation-based, case-control study.
settingNorth NHS region of Scotland. POPULATION: All cases of pregnant, intrapartum and postpartum women with International Classification of Disease-9 codes for sepsis or severe sepsis recorded in the Aberdeen Maternal and Neonatal Databank (AMND) from 1986 to 2009. Four controls per case selected from the AMND were frequency matched on year-of-delivery.
methodsCases and controls were compared; significant variables from univariable regression were adjusted in a multivariable logistic regression model.
main outcome measuresDependent variables were uncomplicated sepsis or severe ('near-miss') sepsis. Independent variables were demographic, medical and clinical delivery characteristics. Unadjusted and adjusted odds ratios (OR) with 95% confidence intervals (95% CI) are reported.
resultsControlling for mode of delivery and demographic and clinical factors, obese women had twice the odds of uncomplicated sepsis (OR 2.12; 95% CI 1.14-3.89) compared with women of normal weight. Age <25 years (OR 5.15; 95% CI 2.43-10.90) and operative vaginal delivery (OR 2.20; 95% CI 1.02-4.87) were also significant predictors of sepsis. Known risk factors for maternal sepsis were also significant in this study (OR for uncomplicated and severe sepsis respectively): multiparity (OR 6.29, 12.04), anaemia (OR 3.43, 18.49), labour induction (OR 3.92 severe only), caesarean section (OR 3.23, 13.35), and preterm birth (OR 2.46 uncomplicated only).
conclusionsObesity, operative vaginal delivery and age <25 years are significant risk factors for sepsis and should be considered in clinical obstetric care.
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Registered trials
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