Trial reportJournal of consulting and clinical psychology2012
Onset of alcohol or substance use disorders following treatment for adolescent depression.
Trial report in Journal of consulting and clinical psychology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- The Impact of Pharmacotherapy of Childhood-Onset Psychiatric Disorders on the Development of Substance Use Disorders.Journal of child and adolescent psychopharmacology · 2022Pooled it
- Pharmacotherapy interventions for adolescent co-occurring substance use and mental health disorders: a systematic review.Family practice · 2022Pooled it
- Randomized pilot trial of a cognitive-behavioral alcohol, self-harm, and HIV prevention program for teens in mental health treatment.Behaviour research and therapy · 2017Trial
- Trajectories of Functioning Into Emerging Adulthood Following Treatment for Adolescent Depression.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2016Trial
- Anxiety and related outcomes in young adults 7 to 19 years after receiving treatment for child anxiety.Journal of consulting and clinical psychology · 2013Trial
- Longitudinal associations between depression and problematic substance use in the Youth Partners in Care study.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 · 2013Trial
- Substance Misuse Prevalence and Risk Factors in Adolescents and Young Adults With Depression.JAMA network open · 2026Article
- An examination of the impact of treatment on later risk for a substance use disorder in young people with major depressive disorder and bipolar disorder.Journal of mood and anxiety disorders · 2025Article
- Adolescent Treatment Landscape of Depression, Suicidality, and Substance Use Disorder in the US.JAMA health forum · 2025Article
- Substance Use-Related Factors and Recurrent Depression among Former Adolescent Psychiatric Inpatients.European addiction research · 2025Article
- Diagnosing major depressive disorder and substance use disorder using the electronic health record: A preliminary validation study.Journal of mood and anxiety disorders · 2023Article
- The externalizing and internalizing pathways to marijuana use initiation: Examining the synergistic effects of impulsiveness and sensation seeking.Developmental psychology · 2021Article
- The Psychosocial Predictors and Day-Level Correlates of Substance Use Among Participants Recruited via an Online Crowdsourcing Platform in the United States: Daily Diary Study.JMIR public health and surveillance · 2021Article
- Feasibility of an Integrated Treatment Approach for Youth with Depression, Suicide Attempts, and Substance Use Problems.Evidence-based practice in child and adolescent mental health · 2021Article
- Principles of Care for Young Adults With Co-Occurring Psychiatric and Substance Use Disorders.Pediatrics · 2021Article
- Triple trajectories of alcohol use, tobacco use, and depressive symptoms as predictors of cannabis use disorders among urban adults.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2018Article
- Effects of Mindfulness-Based Stress Reduction on Depression in Adolescents and Young Adults: A Systematic Review and Meta-Analysis.Frontiers in psychology · 2018Article
- Primary Pediatric Care Psychopharmacology: Focus on Medications for ADHD, Depression, and Anxiety.Current problems in pediatric and adolescent health care · 2017Review
- Conducting Psychopathology Prevention Research in the RDoC Era.Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2016Article
- Conjoint trajectories of depressive symptoms and delinquent behavior predicting substance use disorders.Addictive behaviors · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 10 institutions in 1 country.
Funding
Abstract
objectiveThis study tested whether positive response to short-term treatment for adolescent major depressive disorder (MDD) would have the secondary benefit of preventing subsequent alcohol use disorders (AUD) or substance use disorders (SUD).
methodFor 5 years, we followed 192 adolescents (56.2% female; 20.8% minority) who had participated in the Treatment for Adolescents with Depression Study (TADS; TADS Team, 2004) and who had no prior diagnoses of AUD or SUD. TADS initial treatments were cognitive behavior therapy (CBT), fluoxetine alone (FLX), the combination of CBT and FLX (COMB), or clinical management with pill placebo (PBO). We used both the original TADS treatment response rating and a more restrictive symptom count rating. During follow-up, diagnostic interviews were completed at 6- or 12-month intervals to assess onset of AUD or SUD as well as MDD recovery and recurrence.
resultsAchieving a positive response to MDD treatment was unrelated to subsequent AUD but predicted a lower rate of subsequent SUD, regardless of the measure of positive response (11.65% vs. 24.72%, or 10.0% vs. 24.5%, respectively). Type of initial MDD treatment was not related to either outcome. Prior to depression treatment, greater involvement with alcohol or drugs predicted later AUD or SUD, as did older age (for AUD) and more comorbid disorders (for SUD). Among those with recurrent MDD and AUD, AUD preceded MDD recurrence in 24 of 25 cases.
conclusionEffective short-term adolescent depression treatment significantly reduces the rate of subsequent SUD but not AUD. Alcohol or drug use should be assessed prior to adolescent MDD treatment and monitored even after MDD recovery.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.