ArticleAlcoholism, clinical and experimental research2012
Risky decision-making: an FMRI study of youth at high risk for alcoholism.
Article in Alcoholism, clinical and experimental research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
69 citing papers in PubMed, 3 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- Meta-analysis and review of functional neuroimaging differences underlying adolescent vulnerability to substance use.NeuroImage · 2020Pooled it
- Neural networks involved in adolescent reward processing: An activation likelihood estimation meta-analysis of functional neuroimaging studies.NeuroImage · 2015Pooled it
- Altered risk-related processing in substance users: imbalance of pain and gain.Drug and alcohol dependence · 2013Pooled it
- Increased forebrain activations in youths with family histories of alcohol and other substance use disorders performing a Go/NoGo task.Alcoholism, clinical and experimental research · 2014Trial
- Decision-making in polydrug amphetamine-type stimulant users: an fMRI study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Trial
- Risk calculation circuit abnormalities plus psychosocial risk variables predict problematic substance use in youth with externalizing disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder.Nature. Mental health · 2025Article
- Differing Effects of Alcohol Use on Epigenetic and Brain Age in Adult Children of Parents with Alcohol Use Disorder.Brain sciences · 2024Article
- Abstinence as Choice: Exploring Voluntary Abstinence from Alcohol Self-Administration Using the Resurgence-as-Choice Framework.Perspectives on behavior science · 2024Article
- Neural responses to reward, threat, and emotion regulation and transition to hazardous alcohol use.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Article
- Sex moderates family history of alcohol use disorder and childhood maltreatment effects on an fMRI stop-signal task.Human brain mapping · 2023Article
- The Genetically Informed Neurobiology of Addiction (GINA) model.Nature reviews. Neuroscience · 2023Review
- Visualization of the Dynamic Brain Activation Pattern during a Decision-Making Task.Brain sciences · 2022Article
- Identifying alcohol misuse biotypes from neural connectivity markers and concurrent genetic associations.Translational psychiatry · 2022Article
- Baseline brain and behavioral factors distinguish adolescent substance initiators and non-initiators at follow-up.Frontiers in psychiatry · 2022Article
- Understanding the neurodynamic process of decision-making for mobile application downloading.PloS one · 2022Article
- Ventral striatal resting-state functional connectivity in adolescents is associated with earlier onset of binge drinking.Drug and alcohol dependence · 2021Article
- High Trait Attention Promotes Resilience and Reduces Binge Drinking Among College Students With a Family History of Alcohol Use Disorder.Frontiers in psychiatry · 2021Article
- Behavioral and brain signatures of substance use vulnerability in childhood.Developmental cognitive neuroscience · 2020Article
- Differential Behavioral and Neural Profiles in Youth With Conduct Problems During Risky Decision-Making.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2020Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAdolescents with a family history of alcoholism (FHP) are at risk for developing an alcohol use disorder (AUD), and some studies indicate that FHP individuals show deficits in executive functioning. The ability to make adaptive decisions is one aspect of successful executive functioning that is often measured during risk-taking tasks; however, this behavior has not been examined in FHP youth. As impaired decision-making could predispose FHP youth to make poor choices related to alcohol use, the current study examined the neural substrates of risk-taking in FHP adolescents and their family history negative (FHN) peers.
methodsThirty-one (18 FHP, 13 FHN) youth between 13 and 15 years old were included in this study. All youth had used little to no alcohol prior to study involvement. Functional magnetic resonance imaging was used to examine the neural substrates of risk-taking during the Wheel of Fortune (WOF) decision-making task (Ernst et al., 2004) in FHP and FHN youth.
resultsFHP youth did not differ from FHN youth in risk-taking behavior, but showed less brain response during risky decision-making in right dorsolateral prefrontal cortex and right cerebellar regions compared with FHN peers.
conclusionsDespite no behavioral differences on the WOF decision-making task, FHP youth exhibited atypical neural response during risk-taking compared with FHN peers. Atypical brain activity, in regions implicated in executive functioning could lead to reduced cognitive control, which may result in risky choices regarding alcohol use. This could help explain the higher rates of AUDs seen in FHP adolescents. Further examination of risky behavior and associated brain response over the course of adolescence is necessary to characterize the vulnerabilities of FHP youth in the absence of alcohol abuse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.