ReviewNature reviews. Nephrology2012
A novel pathogenetic concept-antiviral immunity in lupus nephritis.
Review in Nature reviews. Nephrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 55 citations in OpenAlex.
- Lymphotoxin-LIGHT pathway regulates the interferon signature in rheumatoid arthritis.PloS one · 2014Trial
- Neutrophil extracellular traps and acute kidney injury: a narrative review.Frontiers in immunology · 2026Review
- Lupus Nephritis Biomarkers: A Critical Review.International journal of molecular sciences · 2024Review
- Characterization of virus-mediated autoimmunity and the consequences for pathological process in patients with systemic lupus erythematosus.Clinical rheumatology · 2023Article
- Targeting DAMPs with nucleic acid scavengers to treat lupus.Translational research : the journal of laboratory and clinical medicine · 2022Review
- Identification and Validation of IFI44 as Key Biomarker in Lupus Nephritis.Frontiers in medicine · 2021Article
- Lupus nephritis.Nature reviews. Disease primers · 2020Review
- Toll-like receptors in lupus nephritis.Journal of biomedical science · 2018Review
- Investigation of MicroRNA in Mitochondrial Apoptotic Pathway in Systemic Lupus Erythematosus.BioMed research international · 2018Article
- The role of extracellular histone in organ injury.Cell death & disease · 2017Review
- Tofacitinib Ameliorates Murine Lupus and Its Associated Vascular Dysfunction.Arthritis & rheumatology (Hoboken, N.J.) · 2017Article
- Glomerular disease: Personalized immunomonitoring in lupus and lupus nephritis.Nature reviews. Nephrology · 2016Article
- Links between coagulation, inflammation, regeneration, and fibrosis in kidney pathology.Laboratory investigation; a journal of technical methods and pathology · 2016Review
- Unmet medical needs in lupus nephritis: solutions through evidence-based, personalized medicine.Clinical kidney journal · 2015Article
- Targeting C-Reactive Protein in Inflammatory Disease by Preventing Conformational Changes.Mediators of inflammation · 2015Review
- The effect of cell death in the initiation of lupus nephritis.Clinical and experimental immunology · 2015Review
- Pentraxin 3 Plasma Levels and Disease Activity in Systemic Lupus Erythematosus.Autoimmune diseases · 2015Article
- Pattern recognition receptors and the inflammasome in kidney disease.Nature reviews. Nephrology · 2014Review
- Beyond tissue injury-damage-associated molecular patterns, toll-like receptors, and inflammasomes also drive regeneration and fibrosis.Journal of the American Society of Nephrology : JASN · 2014Review
- Immunopathology of lupus nephritis.Seminars in immunopathology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lupus nephritis is a complication of systemic lupus erythematosus, a heterogeneous autoimmune syndrome involving multiple pathways. Accumulating data from the fields of genetics, clinical science, transcriptomics and basic immunology indicate that antiviral immunity has relevance in the pathogenesis of lupus nephritis. This idea is based on the existence of genetic variants that promote the persistence of nuclear particles in the extracellular space or inside lysosomes. Such nuclear particles mimic viral particles and their RNA or DNA components activate viral nucleic acid recognition receptors in antigen-presenting cells. These autoadjuvant effects of endogenous nucleic acids promote an inappropriate immune interpretation of the nuclear particles during antigen presentation. This process fosters the expansion of autoreactive T cells and B cells, which promotes autoantibody production and immune complex glomerulonephritis. The release of interferon α sets off an antiviral immune response with a coordinated induction of hundreds of antiviral genes both inside and outside the kidney. In this article we summarize the available data indicating that innate immunity triggers antiviral immunity in systemic lupus erythematosus. We also discuss the related implications for innovative therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.