ArticleJournal of gastroenterology2012
Analysis of colorectal cancer morphology in relation to sex, age, location, and family history.
Article in Journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Prognostic value of primary tumor location in colorectal cancer: an updated meta-analysis.Clinical and experimental medicine · 2023Pooled it
- Impact of tumor budding on recurrence risk prediction in stage I-III colorectal cancer: a Swedish cohort study.American journal of clinical pathology · 2026Article
- Does side matter? Deciphering mechanisms that underpin side-dependent pathogenesis and therapy response in colorectal cancer.Molecular cancer · 2025Review
- Multidimensional differences of right- and left-sided colorectal cancer and their impact on targeted therapies.NPJ precision oncology · 2025Review
- Impact of Sidedness of Colon Cancer on Epidemiological, Clinical Presentation, Surgical, Pathological, and Oncologic Outcomes.Journal of personalized medicine · 2024Article
- Article
- Is it possible to adopt the same oncological approach in urgent surgery for colon cancer?World journal of clinical oncology · 2022Article
- Colorectal cancer and the blood loss paradox.Frontline gastroenterology · 2022Article
- Evidence for improved prognosis of colorectal cancer diagnosed following the detection of iron deficiency anaemia.Scientific reports · 2021Article
- Article
- Article
- Contrasting Prognostic Effects of Tumor-Infiltrating Lymphocyte Density in Cardia and Non-cardia Gastric Adenocarcinomas.Journal of gastric cancer · 2020Article
- Primary tumor location affects recurrence-free survival for patients with colorectal liver metastases after hepatectomy: a propensity score matching analysis.World journal of surgical oncology · 2020Article
- UEG Week 2019 Poster Presentations.United European gastroenterology journal · 2019Article
- Prognostic Implications of Extranodal Extension in Relation to Colorectal Cancer Location.Cancer research and treatment · 2019Article
- Colon Cancer Sidedness, Presentation, and Survival at Different Stages.Journal of oncology · 2019Article
- Different Anatomical Subsites of Colon Cancer and Mortality: A Population-Based Study.Gastroenterology research and practice · 2018Article
- The predictive effect of primary tumour location in the treatment of metastatic colorectal cancer: a Canadian consensus statement.Current oncology (Toronto, Ont.) · 2017Article
- Association Between Prognosis and Tumor Laterality in Early-Stage Colon Cancer.JAMA oncology · 2017Article
- Poor prognosis of young patients with colorectal cancer: a retrospective study.International journal of colorectal disease · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies of colorectal cancer (CRC) have suggested different mechanisms of carcinogenesis in men and women, young and old patients, right- and left sided tumors, and sporadic and familial tumors. These differences might be reflected in morphology.
methodsCRCs from 1613 patients operated on in 2004-2006 in Sweden were histologically reviewed. Morphology was examined in relation to sex, age groups, location, and family history.
resultsTumors in the right colon were larger, of higher stage, more often poorly differentiated, more mucin-producing, more often had a peritumoral lymphocytic infiltrate and a high level of tumor-infiltrating lymphocytes (TILs), and more seldom had an infiltrating margin than tumors in the left colon and rectum (p < 0.0001 for most features). Young patients (<60 years) more seldom had multiple tumors but more often had perineural invasion, an infiltrative tumor margin, and high-stage tumors. Three features, TILs, medullary tumors, and invasive tumor margin, were related to sex. Only vascular invasion was related to familiality.
conclusionLocation is the factor that has the most influence on tumor morphology. The results support the idea that different carcinogenic mechanisms may be involved in the right and left colon. Age is the most important determinant for the presence of multiple tumors and is a crucial factor for the aggressiveness of the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.