ArticleBioorganic & medicinal chemistry2012
Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives.
Article in Bioorganic & medicinal chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 70 citations in OpenAlex.
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- Flavivirus proteases: The viral Achilles heel to prevent future pandemics.Antiviral research · 2023Review
- Targeting the protease of West Nile virus.RSC medicinal chemistry · 2021Review
- Facile Synthesis and In Vitro Activity ofPathogens (Basel, Switzerland) · 2021Article
- Structure-Based Design, Synthesis, and Biological Evaluation of Triazole-Based smHDAC8 Inhibitors.ChemMedChem · 2020Article
- Co-cultivation ofFrontiers in microbiology · 2019Article
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- An expeditious and efficient bromomethylation of thiols: enabling bromomethyl sulfides as useful building blocks.RSC advances · 2018Article
- Identification of new potent inhibitors of dengue virus NS3 protease from traditional Chinese medicine database.Virusdisease · 2016Article
- Conformational flexibility of DENV NS2B/NS3pro: from the inhibitor effect to the serotype influence.Journal of computer-aided molecular design · 2016Article
- C-terminal residue optimization and fragment merging: discovery of a potent Peptide-hybrid inhibitor of dengue protease.ACS medicinal chemistry letters · 2014Article
- Computer Aided Screening of Phytochemicals from Garcinia against the Dengue NS2B/NS3 Protease.Bioinformation · 2014Article
- The flavivirus protease as a target for drug discovery.Virologica Sinica · 2013Review
- New binding site conformations of the dengue virus NS3 protease accessed by molecular dynamics simulation.PloS one · 2013Article
- Design, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: potent inhibitors of Dengue and West Nile virus NS2B/NS3 proteases.Bioorganic & medicinal chemistry · 2013Article
- Inhibitors of Dengue virus and West Nile virus proteases based on the aminobenzamide scaffold.Bioorganic & medicinal chemistry · 2012Article
- Synthesis of 1,2,3-triazole derivatives and in vitro antifungal evaluation on Candida strains.Molecules (Basel, Switzerland) · 2012Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Two click chemistry-derived focused libraries based on the benz[d]isothiazol-3(2H)-one scaffold were synthesized and screened against Dengue virus and West Nile virus NS2B-NS3 proteases. Several compounds (4l, 7j-n) displayed noteworthy inhibitory activity toward Dengue virus NS2B-NS3 protease in the absence and presence of added detergent. These compounds could potentially serve as a launching pad for a hit-to-lead optimization campaign.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.