ArticleSaudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
The association of metabolic syndrome, insulin resistance and non-alcoholic fatty liver disease in overweight/obese children.
Article in Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Prevalence of the metabolic syndrome in African populations: A systematic review and meta-analysis.PloS one · 2023Pooled it
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- Nonalcoholic fatty liver disease and insulin resistance in children.Clinical and experimental pediatrics · 2023Article
- From Nonalcoholic Fatty Liver Disease (NAFLD) to Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD)-New Terminology in Pediatric Patients as a Step in Good Scientific Direction?Journal of clinical medicine · 2021Review
- Efficacy and safety of traditional Chinese medicines for non-alcoholic fatty liver disease: a systematic literature review of randomized controlled trials.Chinese medicine · 2021Review
- Risk factors and morbidities associated with childhood obesity in sub-Saharan Africa: a systematic scoping review.BMC nutrition · 2020Article
- Is subclinical atherosclerosis associated with visceral fat and fatty liver in adolescents with type 1 diabetes?Archives of medical science : AMS · 2018Article
- Dyslipidemia and Fatty Liver Disease in Overweight and Obese Children.Journal of obesity · 2018Observational
- Natural History of NAFLD Diagnosed in Childhood: A Single-Center Study.Children (Basel, Switzerland) · 2017Article
- The role of elevated alanine aminotransferase (ALT), FasL and atherogenic dyslipidemia in type II diabetes mellitus.Journal of Taibah University Medical Sciences · 2017Article
- Obese Children with Metabolic Syndrome Have 3 Times Higher Risk to Have Nonalcoholic Fatty Liver Disease Compared with Those without Metabolic Syndrome.International journal of endocrinology · 2017Article
- Correlation between severity of ultrasonographic nonalcoholic fatty liver disease and cardiometabolic risk among Filipino wellness patients.Journal of cardiovascular and thoracic research · 2017Article
- Iron Status and Metabolic Syndrome in Patients with Non-Alcoholic Fatty Liver Disease.Middle East journal of digestive diseases · 2016Article
- Nonalcoholic fatty liver disease and the heart in children and adolescents.World journal of gastroenterology · 2014Article
- Biochemical, anthropometric and body composition indicators as predictors of hepatic steatosis in obese adolescents.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2014Article
- Nonalcoholic Fatty liver disease/non-alcoholic steatohepatitis in childhood: endocrine-metabolic "mal-programming".Hepatitis monthly · 2014Review
- Metabolic syndrome, insulin resistance and Fatty liver in obese Iranian children.Iranian Red Crescent medical journal · 2014Article
- Association between UCP3 gene polymorphisms and nonalcoholic fatty liver disease in Chinese children.World journal of gastroenterology · 2013Article
- Skin tags: a link between lesional mast cell count/tryptase expression and obesity and dyslipidemia.Indian journal of dermatology · 2013Article
- What is the role of adiponectin in obesity related non-alcoholic fatty liver disease?World journal of gastroenterology · 2013Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimTo study the prevalence of metabolic syndrome (MS), insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD) in overweight/obese children with clinical hepatomegaly and/or raised alanine aminotransferase (ALT). PATIENTS AND
methodsThirty-three overweight and obese children, aged 2-13 years, presenting with hepatomegaly and/or raised ALT, were studied for the prevalence of MS, IR and NAFLD. Laboratory analysis included fasting blood glucose, serum insulin, serum triglycerides (TG), total cholesterol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c) and liver biochemical profile, in addition to liver ultrasound and liver biopsy.
resultsTwenty patients (60.6%) were labeled with MS. IR was present in 16 (48.4%). Fifteen (44%) patients had biopsy-proven NAFLD. Patients with MS were more likely to have NAFLD by biopsy (P=0.001). Children with NAFLD had significantly higher body mass index, waist circumference, ALT, total cholesterol, LDL-c, TG, fasting insulin, and lower HDL-c compared to patients with normal liver histology (P< 0.05) and fitted more with the criteria of MS (80% vs. 44%). IR was significantly more common among NAFLD patients (73% vs. 28%).
conclusionThere is a close association between obesity, MS, IR and NAFLD. Obese children with clinical or biochemical hepatic abnormalities are prone to suffer from MS, IR and NAFLD.
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