ArticleObesity facts2011
Replication of the SH2B1 rs7498665 association with obesity in a Belgian study population.
Article in Obesity facts, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- Gene-Environment Interactions Significantly Alter the Obesity Risk of SH2B1 rs7498665 Carriers.Journal of obesity & metabolic syndrome · 2024Article
- Role of the Beta and Gamma Isoforms of the Adapter Protein SH2B1 in Regulating Energy Balance.Endocrinology · 2023Article
- Race/ethnicity-associated blood DNA methylation differences between Japanese and European American women: an exploratory study.Clinical epigenetics · 2021Article
- The Effect of SH2B1 Variants on Expression of Leptin- and Insulin-Induced Pathways in Murine Hypothalamus.Obesity facts · 2018Article
- Article
- SH2B1 regulation of energy balance, body weight, and glucose metabolism.World journal of diabetes · 2014Review
- Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants.BMC medical genomics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSH2B1 has been identified as an interesting candidate gene for complex obesity through genome-wide association studies. Therefore, we set out to replicate the reported association with rs7498665 in our Belgian study population and to extend our study with an additional tagSNP for the SH2B1 gene region.
methodsWe genotyped both rs7498665 and rs7201929 in a population of 1,045 obese adults and 317 healthy lean individuals. Statistical analyses were performed to evaluate the role of these polymorphisms in the development of obesity.
resultsWe found that the rs7498665 minor allele increases obesity risk by 26% (OR(age-sex adj) = 1.26, 95% CI 1.04-1.52, nominal p = 0.016). Logistic regression showed that the rs7201929 minor allele decreases obesity risk by 24% in the population investigated (OR(age-sex adj) = 0.76, 95% CI 0.61-0.94, nominal p = 0.011). Conditional analyses showed that both associations represent the same association signal (rs7498665 OR(adjusted for rs7201929) = 1.17, 95% CI 0.95-1.45, nominal P = 0.14; rs7201929 OR(adjusted for rs7498665) = 0.82, 95% CI 0.65-1.04, nominal p = 0.10).
conclusionWith the current study we were able to replicate and confirm that the SH2B1 gene locus is significantly associated with complex obesity in a Caucasian population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.