ArticleBrain research bulletin2012
Nucleus accumbens neuronal activity in freely behaving rats is modulated following acute and chronic methylphenidate administration.
Article in Brain research bulletin, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Effects of methylphenidate on quantitative measures of motor function: a systematic review.Frontiers in human neuroscience · 2026Pooled it
- Methylphenidate reduces functional connectivity of nucleus accumbens in brain reward circuit.Psychopharmacology · 2013Trial
- Age differences to methylphenidate-NAc neuronal and behavioral recordings from freely behaving animals.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- PharmGKB summary: methylphenidate pathway, pharmacokinetics/pharmacodynamics.Pharmacogenetics and genomics · 2019Review
- Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats.Brain and behavior · 2018Article
- Comparison of the VTA and LC response to methylphenidate: a concomitant behavioral and neuronal study of adolescent male rats.Journal of neurophysiology · 2017Article
- D1 and D2 specific dopamine antagonist modulate the caudate nucleus neuronal responses to chronic methylphenidate exposure.Journal of neural transmission (Vienna, Austria : 1996) · 2017Article
- Caudate neuronal recording in freely behaving animals following acute and chronic dose response methylphenidate exposure.Pharmacology, biochemistry, and behavior · 2015Article
- Behavioral and neuronal recording of the nucleus accumbens in adolescent rats following acute and repetitive exposure to methylphenidate.Journal of neurophysiology · 2015Article
- Article
- Nucleus accumbens neuronal activity correlates to the animal's behavioral response to acute and chronic methylphenidate.Physiology & behavior · 2014Article
- Acute administration of methylphenidate alters the prefrontal cortex neuronal activity in a dose-response characteristic.Journal of experimental pharmacology · 2014Article
- Acute and chronic dose-response effect of methylphenidate on ventral tegmental area neurons correlated with animal behavior.Journal of neural transmission (Vienna, Austria : 1996) · 2014Article
- Adult female rats' altered diurnal locomotor activity pattern following chronic methylphenidate treatment.Journal of neural transmission (Vienna, Austria : 1996) · 2013Article
- Behavioral daily rhythmic activity pattern of adolescent female rat is modulated by acute and chronic cocaine.Journal of neural transmission (Vienna, Austria : 1996) · 2013Article
- Dorsal raphe neuronal activities are modulated by methylphenidate.Journal of neural transmission (Vienna, Austria : 1996) · 2013Article
- Methylphenidate modulates the locus ceruleus neuronal activity in freely behaving rat.European journal of pharmacology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Methylphenidate (MPD) is a psychostimulant that enhances dopaminergic neurotransmission in the central nervous system by using mechanisms similar to cocaine and amphetamine. The mode of action of brain circuitry responsible for an animal's neuronal response to MPD is not fully understood. The nucleus accumbens (NAc) has been implicated in regulating the rewarding effects of psychostimulants. The present study used permanently implanted microelectrodes to investigate the acute and chronic effects of MPD on the firing rates of NAc neuronal units in freely behaving rats. On experimental day 1 (ED1), following a saline injection (control), a 30 min baseline neuronal recording was obtained immediately followed by a 2.5 mg/kg i.p. MPD injection and subsequent 60 min neuronal recording. Daily 2.5 mg/kg MPD injections were given on ED2 through ED6 followed by 3 washout days (ED7 to ED9). On ED10, neuronal recordings were resumed from the same animal after a saline and MPD (rechallenge) injection exactly as obtained on ED1. Sixty-seven NAc neuronal units exhibited similar wave shape, form and amplitude on ED1 and ED10 and their firing rates were used for analysis. MPD administration on ED1 elicited firing rate increases and decreases in 54% of NAc units when compared to their baselines. Six consecutive MPD administrations altered the neuronal baseline firing rates of 85% of NAc units. MPD rechallenge on ED10 elicited significant changes in 63% of NAc units. These alterations in firing rates are hypothesized to be through mechanisms that include D1 and D2-like DA receptor induced cellular adaptation and homeostatic adaptations/deregulation caused by acute and chronic MPD administration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.