ArticleComputer methods in biomechanics and biomedical engineering2013
A coupled biventricular finite element and lumped-parameter circulatory system model of heart failure.
Article in Computer methods in biomechanics and biomedical engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Building Digital Twins for Cardiovascular Health: From Principles to Clinical Impact.Journal of the American Heart Association · 2024Review
- Embedded Computational Heart Model for External Ventricular Assist Device Investigations.Cardiovascular engineering and technology · 2022Article
- In vivo estimation of passive biomechanical properties of human myocardium.Medical & biological engineering & computing · 2018Article
- Investigating the Role of Interventricular Interdependence in Development of Right Heart Dysfunction During LVAD Support: A Patient-Specific Methods-Based Approach.Frontiers in physiology · 2018Article
- Construction and Validation of Subject-Specific Biventricular Finite-Element Models of Healthy and Failing Swine Hearts From High-Resolution DT-MRI.Frontiers in physiology · 2018Article
- I-Wire Heart-on-a-Chip II: Biomechanical analysis of contractile, three-dimensional cardiomyocyte tissue constructs.Acta biomaterialia · 2017Article
- Compliance Accelerates Relaxation in Muscle by Allowing Myosin Heads to Move Relative to Actin.Biophysical journal · 2016Article
- Finite-Element Extrapolation of Myocardial Structure Alterations Across the Cardiac Cycle in Rats.Journal of biomechanical engineering · 2015Article
- Biventricular finite element modeling of the Acorn CorCap Cardiac Support Device on a failing heart.The Annals of thoracic surgery · 2013Article
- Left ventricular finite element model bounded by a systemic circulation model.Journal of biomechanical engineering · 2013Article
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Authors and funding
9 authors.
Funding
Abstract
Numerical modelling of the cardiovascular system is becoming an important tool for assessing the influence of heart disease and treatment therapies. In the current study, we present an approach for modelling the interaction between the heart and the circulatory system. This was accomplished by creating animal-specific biventricular finite element (FE) models, which characterise the mechanical response of the heart, and by coupling them to a lumped-parameter model that represents the systemic and pulmonic circulatory system. In order to minimise computation time, the coupling was enforced in a weak (one-way) manner, where the ventricular pressure-volume relationships were generated by the FE models and then passed into the circulatory system model to ensure volume conservation and physiological pressure changes. The models were first validated by tuning the parameters, such that the output of the models matched experimentally measured pressures and volumes. Then the models were used to examine cardiac function and the myofibre stress in a healthy canine heart and a canine heart with dilated cardiomyopathy. The results showed good agreement with experimental measurements. The stress in the case of cardiomyopathy was found to increase significantly, while the pump function was decreased, compared to the healthy case. The total runtime of the simulations is lesser than that of many fully coupled models presented in the literature. This will allow for a much quicker evaluation of possible treatment strategies for combating the effects of heart failure, especially in optimisation schemes that require numerous FE simulations.
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