Trial reportActa orthopaedica2012
The effect of adding tobramycin to Simplex P cement on femoral stem micromotion as measured by radiostereometric analysis: a 2-year randomized controlled trial.
Trial report in Acta orthopaedica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- Antibiotics and antiseptics for preventing infection in people receiving revision total hip and knee prostheses: a systematic review of randomized controlled trials.BMC infectious diseases · 2016Pooled it
- A systematic review and meta-analysis of antibiotic-impregnated bone cement use in primary total hip or knee arthroplasty.PloS one · 2013Pooled it
- Radiostereometric analysis of keeled versus pegged glenoid components in total shoulder arthroplasty: a randomized feasibility study.Canadian journal of surgery. Journal canadien de chirurgie · 2017Trial
- Wear of a sequentially annealed polyethylene acetabular liner.Acta orthopaedica · 2014Trial
- Temporal subsidence patterns of cemented polished taper-slip stems: a systematic review.EFORT open reviews · 2021Review
- Antibiotic containing bone cement in prevention of hip and knee prosthetic joint infections: A systematic review and meta-analysis.Journal of orthopaedic translation · 2020Review
- Audiometric threshold shifts after total knee arthroplasty by using gentamicin-loaded bone cementTurkish journal of medical sciences · 2019Article
- Use of antibiotic-loaded cement in total knee arthroplasty.World journal of orthopedics · 2015Review
- Radiostereometry and new prostheses.Acta orthopaedica · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious in vitro research on addition of antibiotics to bone cement has found no statistically significant deterioration in mechanical properties. However, no clinical studies have compared the performance of tobramycin-laden bone cement with that of standard bone cement (Simplex P). PATIENTS AND
methods23 patients (25 hips) were randomized to receive an Exeter (Stryker Orthopaedics) femoral stem cemented with either Simplex P (standard) or Simplex T (tobramycin-laden) cement. There were 2 years of follow-up, with scheduled radiostereometric (RSA) examinations.
resultsAll stems migrated distally and showed some degree of retroversion. No clinically significant differences in stem subsidence or retroversion were found between the Simplex T and Simplex P cement groups after 2 years. Overall subsidence was less than in previous studies, probably due to a postponed initial post-surgical examination. Rates of subsidence in both cement groups were consistent with those from previous studies of Exeter stems.
interpretationSubsidence of the femoral stem after 2 years was similar in the Simplex T (tobramycin-laden) and Simplex P (standard) groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.