ArticleBMC complementary and alternative medicine2012
Cranberry proanthocyanidins inhibit the adherence properties of Candida albicans and cytokine secretion by oral epithelial cells.
Article in BMC complementary and alternative medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 75 citations in OpenAlex.
- New Insights into Cranberry Bioactivity: Polyphenol Composition, Adhesive Effects Against Food Spoilage Yeasts, and Influence on Intestinal Cells.Molecules (Basel, Switzerland) · 2026Article
- Exploring the Benefits of Cranberries in Dentistry: A Comprehensive Review.Biomedicines · 2025Review
- Root canal disinfection and maintenance of the remnant tooth tissues by using grape seed and cranberry extracts.Odontology · 2023Review
- Potential Combinatory Effect of Cannabidiol and Triclosan Incorporated into Sustained Release Delivery System against Oral Candidiasis.Pharmaceutics · 2022Article
- Procyanidins and Their Therapeutic Potential against Oral Diseases.Molecules (Basel, Switzerland) · 2022Review
- Natural Polyphenols for the Preservation of Meat and Dairy Products.Molecules (Basel, Switzerland) · 2022Review
- Protective Effects of Grape Seed Oligomeric Proanthocyanidins in IPEC-J2-Antibiotics (Basel, Switzerland) · 2022Article
- Article
- Design Guidelines for Cationic Pillar[n]arenes that Prevent Biofilm Formation by Gram-Positive Pathogens.ACS infectious diseases · 2021Article
- Zinc Oxide Nanoparticles Prime a Protective Immune Response inFrontiers in microbiology · 2021Article
- Antioxidant Activity of Flavonoids in LPS-Treated IPEC-J2 Porcine Intestinal Epithelial Cells and Their Antibacterial Effect against Bacteria of Swine Origin.Antioxidants (Basel, Switzerland) · 2020Article
- Antifungal Activity of Phenolic and Polyphenolic Compounds from Different Matrices ofMolecules (Basel, Switzerland) · 2020Review
- Anandamide prevents the adhesion of filamentous Candida albicans to cervical epithelial cells.Scientific reports · 2020Article
- In Vitro Antifungal and Antivirulence Activities of Biologically Synthesized Ethanolic Extract of Propolis-Loaded PLGA Nanoparticles againstEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Growth Media for Mixed Multispecies Oropharyngeal Biofilm Compositions on Silicone.BioMed research international · 2019Article
- Antimicrobial potential of endocannabinoid and endocannabinoid-like compounds against methicillin-resistant Staphylococcus aureus.Scientific reports · 2018Article
- Cranberry-derived proanthocyanidins induce a differential transcriptomic response within Candida albicans urinary biofilms.PloS one · 2018Article
- Bacteria-Derived Carbon Dots Inhibit Biofilm Formation ofFrontiers in microbiology · 2018Article
- Procyanidin A2 Modulates IL-4-Induced CCL26 Production in Human Alveolar Epithelial Cells.International journal of molecular sciences · 2016Article
- Cranberries and Cancer: An Update of Preclinical Studies Evaluating the Cancer Inhibitory Potential of Cranberry and Cranberry Derived Constituents.Antioxidants (Basel, Switzerland) · 2016Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOral candidiasis is a common fungal disease mainly caused by Candida albicans. The aim of this study was to investigate the effects of A-type cranberry proanthocyanidins (AC-PACs) on pathogenic properties of C. albicans as well as on the inflammatory response of oral epithelial cells induced by this oral pathogen.
methodsMicroplate dilution assays were performed to determine the effect of AC-PACs on C. albicans growth as well as biofilm formation stained with crystal violet. Adhesion of FITC-labeled C. albicans to oral epithelial cells and to acrylic resin disks was monitored by fluorometry. The effects of AC-PACs on C. albicans-induced cytokine secretion, nuclear factor-kappa B (NF-κB) p65 activation and kinase phosphorylation in oral epithelial cells were determined by immunological assays.
resultsAlthough AC-PACs did not affect growth of C. albicans, it prevented biofilm formation and reduced adherence of C. albicans to oral epithelial cells and saliva-coated acrylic resin discs. In addition, AC-PACs significantly decreased the secretion of IL-8 and IL-6 by oral epithelial cells stimulated with C. albicans. This anti-inflammatory effect was associated with reduced activation of NF-κB p65 and phosphorylation of specific signal intracellular kinases.
conclusionAC-PACs by affecting the adherence properties of C. albicans and attenuating the inflammatory response induced by this pathogen represent potential novel therapeutic agents for the prevention/treatment of oral candidiasis.
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